{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:57:49Z","timestamp":1784865469919,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Empty nose syndrome (ENS) is commonly treated by surgery, albeit with limited success. Herein, we introduce our experience of applying a newly developed \u201c3D\u2010printed nasal plug\u201d as an alternative conservative treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 20 patients (14 males, 6 females; mean age 46.5\u2009\u00b1\u200913.5\u2009years) with ENS who underwent the application of the 3D\u2010printed nasal plug at Asan Medical Center between June 2022 and May 2023. Symptom improvement was assessed by Empty Nose Syndrome 6\u2010Item Questionnaire (ENS6Q) before and after applying the nasal plug. Clinical results, such as duration and frequency of plug use, discomfort, and level of satisfaction, were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up duration was 40.3\u2009\u00b1\u200924.2\u2009weeks. The average duration of nasal plug usage was 10.8\u2009h per day and 5.3\u2009days a week. The ENS6Q scores improved from 19.6\u2009\u00b1\u20094.6 to 6.8\u2009\u00b1\u20095.1 (mean reduction 12.8\u2009\u00b1\u20095.9) after 30\u2009minutes of wearing. Symptom \u201cnose feelings too open\u201d was improved most by a score of 3.0\u2009\u00b1\u20091.5 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Thirteen patients (65.0%) reported that the effectiveness of the plug, initially confirmed at the first wearing, was well maintained during the entire follow\u2010up. Four patients (20.0%) wore the nasal plug uninterruptedly throughout the week, whereas nine patients (45.0%) wore it intermittently as needed. Frequently reported complaints with plug usage were \u2018displacement of the plug\u2019 and \u2018cosmetic concerns\u2019 about the visible hook portion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 3D\u2010designed nasal plug can be a useful conservative treatment option for ENS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:3935\u20133940, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31414","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T07:26:25Z","timestamp":1711610785000},"page":"3935-3940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Application of a Novel <scp>3D\u2010Printed<\/scp> Nasal Plug as a Conservative Treatment for Empty Nose Syndrome"],"prefix":"10.1002","volume":"134","author":[{"given":"Jang Wook","family":"Gwak","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don\u2010Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Digital Content University of Ulsan  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-0388","authenticated-orcid":false,"given":"Yong Ju","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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