{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:09:34Z","timestamp":1774465774780,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To comprehensively analyze reported cases of nasolacrimal squamous cell carcinoma (NLSCC), focusing on risk factors, treatment modalities, and outcomes. Additionally, investigate the impact of human Papillomavirus (HPV) status and histopathological subtypes' impact on prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Pubmed, Embase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>We conducted a systematic literature review to identify relevant studies reporting cases of NLSCC. The review methods adhered to Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. The final update was performed on May 31, 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 72 studies included a total of 313 participants (mean age: 55; 60% male). Longer symptom duration (44.1\u2009\u00b1\u200959.2\u2009months) correlated with recurrence (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), and males exhibited higher mortality rates (19.6% vs. 2.4% in females, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). The overall survival (OS) rate among all patients was 87.1%. Basaloid NLSCC had a worse death outcome (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001). HPV\u2010positive cases showed comparable OS, recurrence, and metastasis rates to the general population (<jats:italic>p<\/jats:italic>\u2009=\u20090.917, 0.851, 0.07, respectively). Comparing treatment approaches (surgery, surgery with adjuvant radiation, chemoradiotherapy [CRT] followed by surgery), no significant differences in 5 and 10\u2010year OS rates or recurrence were observed (<jats:italic>p<\/jats:italic>\u2009=\u20090.4, 0.24, respectively), but 5\u2010year metastasis events were significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). Eye exenteration rates were 31.1%, 20%, and 0% for the respective treatments (<jats:italic>p<\/jats:italic>\u2009=\u20090.089). Induction chemotherapy saved four cases from potential exenteration with favorable prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early detection and diagnosis are of utmost importance in the management of NLSCC. Regardless of the treatment approach, HPV\u2010related NLSCC demonstrated similar outcomes to the general population. Basaloid histology represents the worst subtype in terms of prognosis. Limited adjuvant CRT cases showed improved outcomes and induction chemotherapy's importance was emphasized in recent literature and our shared experience. <jats:italic>Laryngoscope<\/jats:italic>, 134:3892\u20133902, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31426","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T08:58:59Z","timestamp":1713862739000},"page":"3892-3902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of Nasolacrimal <scp>SCC<\/scp> Treatments and Promising Role of <scp>Chemo\u2010Induction<\/scp>: A Case Report and Systematic Review"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-2244","authenticated-orcid":false,"given":"Mohammad Bilal","family":"Alsavaf","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Ohio State University Wexner Medical 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State University  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majd","family":"Issa","sequence":"additional","affiliation":[{"name":"Internal Medicine, Division of Medical Oncology The Ohio State University Wexner Medical Center  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-5313","authenticated-orcid":false,"given":"Nolan B.","family":"Seim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Ohio State University Wexner Medical Center  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-7042","authenticated-orcid":false,"given":"Kyle K.","family":"VanKoevering","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Ohio State University Wexner Medical Center  Columbus Ohio 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