{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:21:01Z","timestamp":1780392061366,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Anastomotic complications after tracheal resection\/cricotracheal resection (TR\/CTR), such as granulation tissue formation, can lead to severe morbidity. The off\u2010label use of nebulized ciprofloxacin\u2010dexamethasone (Ciprodex) for granulation tissue prophylaxis has anecdotally been used after TR\/CTR, especially in pediatric patients. However, its use in the adult population, and its safety and side effect profile post\u2010TR\/CTR has not been reported. This study aims to characterize the incidence of adverse side effects associated with nebulized Ciprodex in post\u2010TR\/CTR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of all patients who underwent TR\/CTR from June 2015 to July 2023 was performed. The use of nebulized Ciprodex (1\u2009mL ciprofloxacin\u2010dexamethasone 0.3%\u20130.1% otic suspension in 4\u2009mL normal saline) while inpatient was evaluated. Potential side effects were defined as oral thrush, ageusia, arthralgia, and allergic reaction, and were recorded for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients underwent TR\/CTR from June 2015 to July 2023. Of these, 53 (72.6%) had documented Ciprodex administration during their postoperative course. One (1.9%) patient reported at least one side effect, including one instance of skin rash (1.9%) and one instance of allergic reaction (1.9%). There were no other side effects attributed to Ciprodex use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of side effects related to the use of nebulized Ciprodex is felt to be minimal in post\u2010TR\/CTR. Although Ciprodex may have the potential to treat granulation tissue in the airway, further studies are needed to verify its efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:3695\u20133697, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31428","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T03:43:10Z","timestamp":1711597390000},"page":"3695-3697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety of Nebulized Ciprodex for <scp>Postoperative<\/scp> Management of Tracheal Resection"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0897-4611","authenticated-orcid":false,"given":"Jason S.","family":"Chwa","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0872-869X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Shuman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Southern California  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-1647","authenticated-orcid":false,"given":"Karla","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Southern California  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26151"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"S160","article-title":"Complications after 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