{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:25:08Z","timestamp":1792841108392,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to investigate the impact of septal perforation (SP) on quality of life (QoL). SP is compared to the general population and patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) using the Sino\u2010Nasal Outcome Test 22 (SNOT\u201022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective single\u2010center study in a referral Rhinology Unit from January 2014 to March 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 392 patients were included in three groups: controls (<jats:italic>n<\/jats:italic>\u2009=\u2009141), CRSwNP (<jats:italic>n<\/jats:italic>\u2009=\u2009118), and SP (<jats:italic>n<\/jats:italic>\u2009=\u2009133). The mean score of the SNOT\u201022 was significantly higher in the CRSwNP group (42.4, SD\u2009=\u200924.4) and SP (46.5, SD\u2009=\u200922) compared to the control group (6.2, SD\u2009=\u20098.4). Scores by either items or domains were significantly higher in the CRSwNP and SP groups compared to the control group. There were no significant differences in the mean SNOT\u201022 between the CRSwNP and SP groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.26; 95% CI \u22121.68\u20139.99). Domain\u2010specific analysis of overall SNOT\u201022 scores revealed that patients with SP experienced higher levels of disturbances in sleep, function, and psychological domains (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SP produces a negative impact on QoL similar to CRSwNP. Moreover, sleep, psychological, and function domains are significantly worse in SP. Etiology and area of SP influence nasal and emotion domain, though more studies on SP using SNOT\u201022 and specific questionnaires are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 134:4480\u20134487, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31557","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T13:18:05Z","timestamp":1717852685000},"page":"4480-4487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quality of Life in Symptomatic Septal Perforation"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-9725","authenticated-orcid":false,"given":"Berta","family":"Alegre Edo","sequence":"first","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department Hospital Cl\u00ednic, Universitat Barcelona, IDIBAPS, CIPERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Rojas\u2010Lechuga","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department Hospital Cl\u00ednic, Universitat Barcelona, IDIBAPS, CIPERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Quer\u2010Castells","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department Hospital Cl\u00ednic, Universitat Barcelona, IDIBAPS, CIPERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesly","family":"Gonz\u00e1lez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department Hospital Cl\u00ednic, Universitat Barcelona, IDIBAPS, CIPERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Lopez\u2010Chacon","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department Hospital Cl\u00ednic, Universitat Barcelona, IDIBAPS, CIPERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hopkins","sequence":"additional","affiliation":[{"name":"ENT Department Guy's and St Thomas' Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-5599","authenticated-orcid":false,"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department Hospital Cl\u00ednic, Universitat Barcelona, IDIBAPS, CIPERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2017.02.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05490-w"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2022.0162"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131609500906"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28415"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-021-00992-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7818"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino16.211"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040925"},{"issue":"1","key":"e_1_2_6_11_1","first-page":"4","article-title":"Quality of life and chronic rhinosinusitis with nasal polyposis. 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