{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:20:15Z","timestamp":1788787215746,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze oncological efficacy and voice outcomes of the 445\u2010nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532\u2010nm potassium\u2010titanyl\u2010phosphate (KTP) laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single institution, retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1\u2010year follow\u2010up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow\u2010up of 635 and 1236\u2009days, respectively. Oncologic outcomes were not significantly different, with disease\u2010specific survival rates of 95.9% for BL and 100% for KTP (<jats:italic>p<\/jats:italic>\u2009=\u20090.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (<jats:italic>p<\/jats:italic>\u2009=\u20090.39), and local control rates of 93.9% for BL and 92.1% for KTP (<jats:italic>p<\/jats:italic>\u2009=\u20090.81). Both BL and KTP groups showed significant improvement in CAPE\u2010V (<jats:italic>p<\/jats:italic>\u2009=\u20090.04, 0.006 respectively) and VHI\u201010 scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.003, &lt;0.00001) following surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photoangiolytic removal of early glottic carcinoma with BL appears to be equally safe and effective as with KTP laser at minimum one\u2010year follow\u2010up, and with excellent voice outcomes. Additional study will be warranted over time to assess long\u2010term outcomes in BL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 134:4656\u20134660, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31569","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T09:32:56Z","timestamp":1718098376000},"page":"4656-4660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of the 445\u2010nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1\u2010Year Results"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-0158","authenticated-orcid":false,"given":"David E.","family":"Rosow","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-7858","authenticated-orcid":false,"given":"Eytan","family":"Keidar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Pasick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas J.","family":"Casellas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mursalin M.","family":"Anis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Facts & Figures 2023","author":"American Cancer Society","year":"2023"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500313"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.10.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197508000-00003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894081170S701"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414538936"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26853"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420938100"},{"key":"e_1_2_6_10_1","unstructured":"Mavadia\u2010ShuklaJ.Food and Drug Administration. 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