{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:46:01Z","timestamp":1769730361951,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To document the 10\u2010year results of transoral mandibular preservation surgery for patients with T1\u20102 squamous cell carcinoma (SCC) arising from the lateral oropharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective 30\u2010year review using STROBE guidelines at an academic, tertiary referral center. A total of 294 patients with T1\u20102 SCC of the lateral oropharynx were reviewed. Only 19% of patients were never\u2010smokers, suggesting a predominantly HPV\u2010negative population. All patients had transoral mandibular preservation surgery. Follow\u2010up therapy included neck dissection (76.5%), induction chemotherapy (57.8%), and postoperative radiation therapy (31.6%) Local control, survival, and functional endpoints, as well as the consequences of local recurrence, were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 10\u2010year local disease control was 88.3%. Local recurrence was salvaged in 50% of cases, resulting in an overall 94.5% local control rate. The overall 10\u2010year survival was 50%. Mortality was related to metachronous second primary cancer (MSPC) (29.2%), medical comorbidities (25.7%), uncontrolled local recurrence (10%), and complications following transoral resection (4.2%). In multivariate analysis, the development of an MSPC significantly increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005) the risk of death. Overall, 95.2% of patients achieved mandibular preservation. However, gastrostomy and tracheostomy dependence occurred in 1% and 0.3% of cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For a patient population with a significant percentage of tobacco\u2010associated oropharyngeal cancer (OPC), transoral surgery was associated with long\u2010term minimal postoperative complications and a high rate of local control. MSPC was the main cause of death during the first 10 postoperative years. Such long\u2010term figures support transoral surgery as an effective first\u2010line treatment for early\u2010stage predominantly tobacco\u2010related OPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:4564\u20134572, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31574","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:31:52Z","timestamp":1719311512000},"page":"4564-4572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ten\u2010Year Efficacy of Transoral Surgery for Squamous Carcinoma of the Lateral Oropharynx"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-6761","authenticated-orcid":false,"given":"Ollivier","family":"Laccourreye","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Service d'Otorhinolaryngologie et de Chirurgie Cervico\u2010Faciale, HEGP, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Service d'Otorhinolaryngologie et de Chirurgie Cervico\u2010Faciale, HEGP, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-5287","authenticated-orcid":false,"given":"Arifeen","family":"Rahman","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Surgery, Department of Otolaryngology Stanford University  Palo Alto California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-1414","authenticated-orcid":false,"given":"F. Christopher","family":"Holsinger","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Surgery, Department of Otolaryngology Stanford University  Palo Alto California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"issue":"7","key":"e_1_2_7_2_1","first-page":"433","article-title":"Electrocoagulation in epitheliomas of the tonsils","volume":"68","author":"Huet PC","year":"1951","journal-title":"Ann Otolaryngol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.7.583"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.7.592"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0347(200005)22:3<294::aid-hed13>3.0.co;2-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00618.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20124"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1220"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.02.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2014.03.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13359"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25674"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2015.07.002"},{"key":"e_1_2_7_16_1","first-page":"1358","article-title":"Multiple primary malignant tumors: a survey of the literature and statistical study","volume":"16","author":"Warren SGO","year":"1932","journal-title":"Am J Cancer"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1536"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_7_19_1","unstructured":"EQUATOR.Network | Enhancing the QUAlity and Transparency Of Health Research.2024.https:\/\/www.equator-network.org\/."},{"key":"e_1_2_7_20_1","unstructured":"Particulier | CNIL.2024.https:\/\/www.cnil.fr\/fr."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2017.06.002"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.3157"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.08.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.7.751"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6995"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.3870"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26776"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21669"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2335-6"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.5097"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813503446"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414558109"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820968800"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29951"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2019.09.015"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900050063008"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29659"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:40:06Z","timestamp":1750668006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/lary.31574"],"URL":"https:\/\/doi.org\/10.1002\/lary.31574","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2024-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}