{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:18:22Z","timestamp":1775571502764,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Vocal cord fixation is one of the main upstaging features of laryngeal cancer. In our previously conducted retrospective study, vocal cord (VC) mobility restoration after chemoradiotherapy was a favorable prognostic variable. In this prospective study, we examined the significance of VC mobility restoration after definitive treatment as a prognostic variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, we enrolled 30 patients with squamous cell carcinoma of the larynx with VC impairment\/fixation (T2\/3, T4a) who underwent definitive chemoradiotherapy with complete response. Video laryngoscopy before and at 3\u2009months after treatment was used to evaluate VC mobility. The primary endpoint of the study was the local recurrence\u2010free probability. Secondary endpoints included recurrence\u2010free probability, disease\u2010specific survival (DSS), and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of patients was 62\u2009years (IQR 54\u201367). The primary subsites were the glottis (<jats:italic>n<\/jats:italic>\u2009=\u200913) and supraglottis (<jats:italic>n<\/jats:italic>\u2009=\u200914). After treatment, 18 (60%) patients had a full recovery of VC mobility, and 12 (40%) patients' VCs were fixed or impaired. Five\u2010year local recurrence\u2010free probability was worse in the VC\u2010impaired group compared to a group with restored VC mobility (46% vs. 85%, <jats:italic>p<\/jats:italic>\u2009=\u20090.012). Recurrence\u2010free probability, OS, and DSS differences were not statistically significant in both groups. VC mobility restoration predicted local recurrence\u2010free probability on univariable analysis (HR 6.15, 95% CI 1.23\u201330.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this prospective study, we show that the absence of VC mobility restoration is associated with worse local recurrence\u2010free probability after definitive laryngeal preservation treatment. Patients with persistent vocal cord immobility warrant closer follow\u2010up to detect recurrence early.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 135:671\u2013676, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31608","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T10:49:37Z","timestamp":1719830977000},"page":"671-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vocal Cord Function Return After Larynx Preservation is Associated With Recurrence\u2010Free Probability"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-2019","authenticated-orcid":false,"given":"Dauren","family":"Adilbay","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head Neck Surgery Louisiana State University of Health Sciences  Shreveport Louisiana U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-8746","authenticated-orcid":false,"given":"Ameya A.","family":"Asarkar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head Neck Surgery Louisiana State University of Health Sciences  Shreveport Louisiana U.S.A."},{"name":"Feist Weiller Cancer Center  Shreveport Louisiana U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-0769","authenticated-orcid":false,"given":"Rema Anisha","family":"Kandula","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head Neck Surgery Louisiana State University of Health Sciences  Shreveport Louisiana U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Moore\u2010Medline","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head Neck Surgery Louisiana State University of Health Sciences  Shreveport Louisiana U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-318X","authenticated-orcid":false,"given":"Cherie\u2010Ann","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head Neck Surgery Louisiana State University of Health Sciences  Shreveport Louisiana U.S.A."},{"name":"Feist Weiller Cancer Center  Shreveport Louisiana U.S.A."},{"name":"Surgical Service Overton Brooks Veterans Affairs Medical Centert  Shreveport Louisiana 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