{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:31:19Z","timestamp":1747150279783,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["NIDCD U24 DC020851\u201001"],"award-info":[{"award-number":["NIDCD U24 DC020851\u201001"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Despite otitis media and various disease processes being associated with endolymphatic hydrops (EH), an exact explanation of the pathophysiology has yet to be reported. This study aimed to investigate the changes in the cochlear lateral wall structures and their potential correlation with the presence and severity of cochlear EH in acute and chronic otitis media cases. The investigations were conducted in both chinchilla animal model and human temporal bone specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied a total of 15 chinchilla and 25 human temporal bones from our collection, which were categorized into acute otitis media, chronic otitis media (COM), and control groups. Through quantitative analysis, we measured the area of cochlear lateral wall structures and observed the presence and the degree of EH using light microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant changes were determined in the area of the spiral ligament (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) across the species. However, a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) decrease in the mean area of the stria vascularis in the basal turn was identified in COM groups compared to controls of both species. Chinchilla model additionally exhibited pathology extending to the lower mid turn. A negative correlation was found between the mean strial area and the severity of EH in both the animal model and human samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COM associated with significant changes in the stria vascularis that may lead to significant increase in the degree of EH. The presented animal model exhibited parallel findings with human samples, suggesting its viability as a valuable model for future studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 134:5103\u20135108, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31626","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T10:38:30Z","timestamp":1720003110000},"page":"5103-5108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Cochlear Lateral Wall Changes and Endolymphatic Hydrops in Otitis Media"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-1157","authenticated-orcid":false,"given":"Nevra","family":"Keskin Yilmaz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine Ankara University  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-6977","authenticated-orcid":false,"given":"Tomotaka","family":"Shimura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Otorhinolaryngology Showa University Fujigaoka Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-3855","authenticated-orcid":false,"given":"Artur","family":"Koerig Schuster","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine: Surgical Sciences Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Rs Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahattin","family":"Cureoglu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9124-593X","authenticated-orcid":false,"given":"Rafael da costa","family":"Monsanto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; 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