{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:30:54Z","timestamp":1773149454193,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The incidence and risk factors for facial nerve dysfunction (FND) following CyberKnife\u00ae therapy for vestibular schwannoma (VS) remain poorly understood. This study investigates whether differential radiation doses to vulnerable segments of the facial nerve may be associated with FND outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were identified who underwent CyberKnife\u00ae radiosurgery for VS at a single institution. Basic demographics, tumor characteristics, and facial nerve function were collected. Total radiation doses to tumor, internal auditory canal (IAC), and labyrinthine segment of facial nerve (LSFN) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six out of 64 patients experienced FND following CyberKnife\u00ae treatment for VS (9.38%, 6\/64). Patients with FND were compared to those without FND (control). Of the 64 patients, complete radiation records were obtained for 30 patients (6 FND vs. 24 control). There were no significant differences in demographic or tumor characteristics between control and FND cohorts. More severe FND (HB\u2009\u2265\u20094) had significantly larger tumors (3.74 vs. 1.27\u2009cm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.037) with directionally decreased time to FND (3.50 vs. 33.5\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.106) than patients with HB\u2009&lt;\u20094, respectively. There were directionally, nonsignificant differences between maximum radiation doses to the LSFN (2492.4 vs. 2557.0\u2009cGy, <jats:italic>p<\/jats:italic>\u2009=\u20090.121) and IAC (2877.3 vs. 2895.5\u2009cGy, <jats:italic>p<\/jats:italic>\u2009=\u20090.824) between the control and FND cohorts, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FND may represent an underrecognized sequelae of CyberKnife\u00ae radiosurgery for VS that can occur many months following treatment. Further studies are needed to elucidate the effect of differential radiation exposure to the facial nerve with FND following treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 (Retrospective Cohort Study) <jats:italic>Laryngoscope<\/jats:italic>, 134:5080\u20135086, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31627","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T12:24:41Z","timestamp":1720095881000},"page":"5080-5086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Delayed Facial Nerve Dysfunction Following <scp>CyberKnife<\/scp>\u00ae Radiosurgery for Vestibular Schwannoma"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-5713","authenticated-orcid":false,"given":"J. Dixon","family":"Johns","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiation\u2010Oncology MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul X.","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Radiation\u2010Oncology MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan R.","family":"Conroy","sequence":"additional","affiliation":[{"name":"Department of Radiation\u2010Oncology MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-7620","authenticated-orcid":false,"given":"Paul F.","family":"Chisolm","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Jeffrey","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3205\/cto000142"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2020394"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2011.02.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400105"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S218670"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818770629"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.1.Jns121370"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.Jns16515"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx512"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.Focus12163"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx511"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz147"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200305000-00017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-020-01380-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.7.Focus12199"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000001162"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31821e192f"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.07.117"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-019-03290-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9842-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(02)03651-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.6.0858"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106109"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0385-8146(97)00049-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841867809127916"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100092"},{"key":"e_1_2_6_28_1","first-page":"207","article-title":"Radiation\u2010induced damage in the central nervous system: an interpretation of target cell responses","volume":"7","author":"Kogel AJ","year":"1986","journal-title":"Br J Cancer Suppl"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90010-2"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-9297-9_24"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.10.012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.1.0001"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817695805"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2014.39840"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109519"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2021.100694"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2014.7.3.157"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:06:38Z","timestamp":1731585998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/lary.31627"],"URL":"https:\/\/doi.org\/10.1002\/lary.31627","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]},"assertion":[{"value":"2024-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}