{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:13:54Z","timestamp":1792026834399,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the saccule\u2010to\u2010utricle ratio in early\u2010 versus late\u2010stage Meniere's disease (MD) patients based on magnetic resonance imaging (MRI) images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we performed 3\u2010dimensional real inversion recovery (3D\u2010real IR) MRI 24\u2009h after intratympanic gadolinium administration in unilateral MD patients at early\u2010stage (<jats:italic>n<\/jats:italic>\u2009=\u200956) and late\u2010stage (<jats:italic>n<\/jats:italic>\u2009=\u200970). Two radiologists independently graded endolymphatic hydrops (EH) and the saccule\u2010to\u2010utricle ratio inversion (SURI) was compared between the two groups. Furthermore, early\u2010stage MD patients were further divided into two subgroups based on disease duration: \u22646\u2009months (<jats:italic>n<\/jats:italic>\u2009=\u200920) and &gt;6\u2009months (<jats:italic>n<\/jats:italic>\u2009=\u200936) and the SURI was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 56 patients in the early\u2010stage group, 26 cases (46.43%) exhibited an enlarged saccule that is larger than the utricle, showing SURI. In contrast, among the late\u2010stage MD, only four cases (5.71%) showed SURI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the early\u2010stage MD subgroup with a disease duration of \u22646\u2009months, the proportion of SURI was 70% (14\/20), which was higher than that in the subgroup with a disease duration of &gt;6\u2009months (33.33%, 12\/36, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SURI may serve as an effective imaging marker for diagnosis of early\u2010stage MD. Our finding suggests that endolymphatic hydrops in MD may primarily originate from the saccule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 134:5116\u20135121, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31655","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T18:55:26Z","timestamp":1722106526000},"page":"5116-5121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparing the Saccule\u2010to\u2010Utricle Ratio in Early\u2010 Versus Late\u2010Stage Meniere's Disease Patients"],"prefix":"10.1002","volume":"134","author":[{"given":"Wenting","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou 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