{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:29:55Z","timestamp":1787869795596,"version":"build-2784847793"},"reference-count":70,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy of the 445\u2010nm blue laser to the 585\u2010nm pulsed dye laser (PDL) and 532\u2010nm potassium\u2010titanyl\u2010phosphate (KTP) laser in the treatment of benign laryngeal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Cochrane Library, PubMed, Scopus, and CINAHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Following PRISMA guidelines, databases were searched from inception through January 29, 2024, for studies reporting the use of photoangiolytic lasers for treatment of benign laryngeal lesions, including the 585\u2010nm PDL, 532\u2010nm KTP laser, and 445\u2010nm blue laser. Outcome measures included lesion resolution (%), mean differences (\u0394) in Voice Handicap Index (VHI\u201010), and summed dysphonia grade, roughness, and breathiness (GRB) scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 studies were included for meta\u2010analysis, consisting of 348 patients treated with PDL, 550 patients with KTP laser, and 338 patients with blue laser. Treatment with blue laser resulted in the greatest lesion resolution (94.0%; 95% confidence interval [CI]: 90.2%\u201396.7%), followed by KTP laser (90.4%; 95% CI: 84.1%\u201395.2%), and PDL (86.9%; 95% CI: 62.9%\u201399.2%). VHI\u201010 improved significantly in patients following treatment with blue laser (\u039413.3; 95% CI: 10.7\u201316.0; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), KTP laser (\u039410.3; 95% CI: 7.4\u201313.3; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and PDL (\u03947.4; 95% CI: 4.8\u201310.1; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). GRB improved significantly in patients following treatment with blue laser (\u03944.1; 95% CI: 2.9\u20135.2; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), KTP laser (\u03943.0; 95% CI: 2.0\u20134.0; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and PDL (\u03942.5; 95% CI: 0.8\u20134.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photoangiolytic lasers are effective in treating benign laryngeal lesions. Blue lasers are promising for laryngeal laser surgery. <jats:italic>Laryngoscope<\/jats:italic>, 134:4847\u20134857, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31658","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T10:36:43Z","timestamp":1723199803000},"page":"4847-4857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Photoangiolytic Lasers for Treatment of Benign Laryngeal Lesions: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-3174","authenticated-orcid":false,"given":"Akash M.","family":"Bhat","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Drexel University College of Medicine  Philadelphia 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Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Meenan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-6319","authenticated-orcid":false,"given":"Robert T.","family":"Sataloff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Drexel University College of Medicine  Philadelphia Pennsylvania 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