{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:31:24Z","timestamp":1747150284985,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["K23DC016335","R01DC016315","UL1TR002494"],"award-info":[{"award-number":["K23DC016335","R01DC016315","UL1TR002494"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Unexplained chronic cough (UCC) is common and has significant impacts on quality of life. Ongoing cough can sensitize the larynx, increasing the urge to cough and perpetuating the cycle of chronic cough. Vibrotactile stimulation (VTS) of the larynx is a noninvasive stimulation technique that can modulate laryngeal somatosensory and motor activity. Study objectives were to assess feasibility and acceptability of VTS use by people with UCC. Secondarily, changes in cough\u2010related quality of life measures were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with UCC recorded cough measures at baseline and after completing 2\u2009weeks of daily VTS. Feasibility and acceptability were assessed through participant\u2010reported device use and structured feedback. Cough\u2010related quality of life measures were the Leicester Cough Questionnaire (LCQ) and the Newcastle Laryngeal Hypersensitivity Questionnaire (NLHQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen adults participated, with mean age 67\u2009years and cough duration 130\u2009months. Notably, 93% of planned VTS sessions were logged, 94% of participants found the device comfortable to wear, 89% found it easy to operate and 79% would recommend it to others. Pre\u2010post LCQ change achieved a minimal important difference (MID) (mean 1.3 [SD 2.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.015]). NLHQ scores improved, but did not reach an MID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laryngeal VTS use was feasible and acceptable for use by patients with UCC and was associated with a meaningful improvement in cough\u2010related quality of life. Future studies will include VTS dose refinement and the inclusion of a comparison arm to further assess the potential for laryngeal VTS as a novel treatment modality for UCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:5010\u20135014, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31673","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T11:02:27Z","timestamp":1722596547000},"page":"5010-5014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngeal Vibrotactile Stimulation Is Feasible, Acceptable To People With Unexplained Chronic Cough"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-6323","authenticated-orcid":false,"given":"Stephanie","family":"Misono","sequence":"first","affiliation":[{"name":"Department of OtoHNS University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin Y.","family":"Shen","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna G.","family":"Sombrio","sequence":"additional","affiliation":[{"name":"Association of Pediatric Program Directors  McLean Virginia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Lunos","sequence":"additional","affiliation":[{"name":"Biostatistical Design and Analysis Center, Clinical and Translational Science Institute University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiapeng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Human Sensorimotor Control Laboratory University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Department of OtoHNS University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Stockness","sequence":"additional","affiliation":[{"name":"Department of OtoHNS University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of OtoHNS University of Minnesota, Lions Voice Clinic  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of OtoHNS University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel T.","family":"Gaeckle","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care and Sleep, Department of Medicine University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-2345","authenticated-orcid":false,"given":"Raluca","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of OtoHNS University of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-5610","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Konczak","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Human Sensorimotor Control Laboratory University of Minnesota  Minneapolis Minnesota 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