{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:47:25Z","timestamp":1788857245972,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Tympanostomy tube placement has been shown to decrease systemic antibiotics usage in patients with recurrent acute otitis media. Systemic antibiotics in children are associated with an increase in antibiotic\u2010associated conditions (asthma, allergic rhinitis, food allergy, atopic dermatitis, celiac disease, overweight\/obesity, attention\u2010deficit hyperactivity disorder [ADHD], autism, learning disability, and <jats:italic>Clostridium difficile<\/jats:italic> colonization) later in life. The objective of this study is to estimate whether tympanostomy tube placement is associated with a reduction in antibiotic\u2010associated conditions in children with recurrent acute otitis media (RAOM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort review of electronic medical records from 1991 to 2011 at a large pediatric hospital system was performed identifying 27,584 patients under 18\u2009years old with RAOM, defined by 3 or more episodes of AOM. Antibiotic\u2010associated conditions were defined using <jats:italic>ICD\u20109<\/jats:italic> and <jats:italic>ICD\u201010<\/jats:italic> codes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The enrollment population was largely composed of White patients (28.9%), Black patients (30.1%), and Hispanic\/Latino patients (16.4%). The number of systemic antibiotics prescribed per encounter was significantly lower in children who pursued tympanostomy tubes (0.14 antibiotics per encounter) versus those who did not (0.23 antibiotics per encounter) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Patients with RAOM who received tympanostomy tubes were less likely to have diagnoses of overweight\/obesity (OR. 0.62 [0.55, 0.68]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), asthma (OR 0.8 [0.74, 0.87]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), allergic rhinitis (OR 0.72 [0.65, 0.81]; p\u2009&lt;\u20090.001), and atopic dermatitis (0.78 [0.71, 0.86]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Tympanostomy tube placement is associated with less systemic antibiotic administration and a decreased incidence of overweight\/obesity, asthma, allergic rhinitis, and atopic dermatitis in children diagnosed with RAOM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31717","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T21:21:45Z","timestamp":1724361705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reduction of Antibiotic\u2010Associated Conditions After Tympanostomy Tube Placement in Children"],"prefix":"10.1002","author":[{"given":"Sivakumar","family":"Chinnadurai","sequence":"first","affiliation":[{"name":"ENT and Facial Plastic Surgery Children's Minnesota  Minneapolis Minnesota USA"},{"name":"Otolaryngology Head and Neck Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Meyer","sequence":"additional","affiliation":[{"name":"ENT and Facial Plastic Surgery Children's Minnesota  Minneapolis Minnesota USA"},{"name":"Research Institute Children's Hospitals and Clinics of Minnesota  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