{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:37:36Z","timestamp":1764333456962,"version":"3.30.2"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oxymetazoline hydrochloride has been shown to be effective in some studies for acquired blepharoptosis and for aesthetic upper eyelid elevation. This study aims to systematically review the literature on the use of topical oxymetazoline for treating acquired blepharoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Databases Reviewed<\/jats:title><jats:p>PubMed (U.S. National Library of Medicine, National Institutes of Health), Scopus (Elsevier), and Cochrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of studies published between 2013 and 2024 following PRISMA guidelines was performed using the PubMed, Scopus, and Cochrane databases. Primary outcomes included pre\u2010 to posttreatment change in marginal reflex distance (MRD1) after treatment with topical oxymetazoline, and mean difference (pre\u2010to\u2010posttreatment) in MRD1 versus control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five articles included data from 458 patients for analysis. Meta\u2010analysis demonstrated significant improvement in MRD1 measurements posttreatment with oxymetazoline (1.40\u2009mm; 95% confidence interval, CI [0.41\u2009mm, 2.40\u2009mm]). In addition, when compared to controls, patients treated with oxymetazoline demonstrated greater increase in MRD1 values (0.83\u2009mm; 95% CI [0.10\u2009mm, 1.55\u2009mmm]). Heterogeneity, measured by <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic, was high in all studies (85%\u201395%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of oxymetazoline 0.1% ophthalmic solution significantly improves MRD1 in patients with acquired blepharoptosis. Further studies comparing this treatment in other etiologies of acquired blepharoptosis should be conducted. <jats:italic>Laryngoscope<\/jats:italic>, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31723","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T21:21:55Z","timestamp":1724361715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Oxymetazoline 0.1% Ophthalmic Solution for Acquired Blepharoptosis: A Systematic Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9223-8616","authenticated-orcid":false,"given":"Mary","family":"Newland","sequence":"first","affiliation":[{"name":"Penn State College of Medicine  Hershey Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e4nel","family":"Eberly","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine  Hershey Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8148-374X","authenticated-orcid":false,"given":"Cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Penn State College of Medicine  Hershey Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessyka G.","family":"Lighthall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Penn State College of Medicine  Hershey Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.2147\/OPTH.S322326","article-title":"Safety of once\u2010daily oxymetazoline HCl ophthalmic solution, 0.1% in patients with acquired blepharoptosis: results from four randomized, double\u2010masked clinical trials","volume":"15","author":"Wirta DL","year":"2021","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1001\/jamaophthalmol.2020.3812","article-title":"Association of oxymetazoline hydrochloride, 0.1%, solution administration with visual field in acquired ptosis: a pooled analysis of 2 randomized clinical trials","volume":"11","author":"Slonim CB","year":"2020","journal-title":"JAMA Ophthalmol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.2147\/OPTH.S306155","article-title":"Rapid and sustained eyelid elevation in acquired blepharoptosis with oxymetazoline 0.1%: randomized phase 3 trial results","volume":"15","author":"Bacharach J","year":"2021","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcro.0000000000000048"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bjps.2023.02.006","article-title":"The effects of topical oxymetazoline on eyelid position, eye redness, and patient\u2010reported eye appearance: a randomized controlled trial","volume":"80","author":"Shoji MK","year":"2023","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/asj\/sjab400","article-title":"Changes to eye whiteness and eyelid\/brow position with topical oxymetazoline in aesthetic patients","volume":"6","author":"Ugradar S","year":"2022","journal-title":"Aesthet Surg J"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan \u2013 a web and mobile app for systematic reviews","volume":"1","author":"Ouzzani M","year":"2016","journal-title":"Syst Rev"},{"key":"e_1_2_6_10_1","unstructured":"HuangX LinJ Demner\u2010FushmanD.Evaluation of PICO as a knowledge representation for clinical questions. 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