{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:57:16Z","timestamp":1787061436074,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM008620"],"award-info":[{"award-number":["T32GM008620"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>There is growing interest in assessing patient quality of life (QOL) following treatment of sinonasal tumors, including inverted papilloma (IP). We aimed to elucidate the natural history of postoperative QOL outcomes in IP patients treated with surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases of sinonasal IP treated surgically at 4 tertiary academic rhinology centers were retrospectively reviewed. SNOT\u201022 scores were used to evaluate QOL preoperatively and postoperatively (1, 3, 6, 12\u2009months). Repeated\u2010measures ANOVA assessed for differences in mean scores over time. Linear regression identified factors associated with QOL longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      373 patients were analyzed. Mean preoperative SNOT\u201022 score was 20.6\u2009\u00b1\u200920.4, which decreased to 16.3\u2009\u00b1\u200918.8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) and 11.8\u2009\u00b1\u200915.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at 1 and 3\u2009months postoperatively, respectively. No further changes in SNOT\u201022 scores occurred beyond 3\u2009months postoperatively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). When analyzed by SNOT\u201022 subdomains, nasal, sleep, and otologic\/facial subdomain scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) demonstrated improvement at 12\u2010month follow\u2010up compared with preoperative scores; this was not observed for the emotional subdomain score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.800). Recurrent cases were associated with higher long\u2010term SNOT\u201022 scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20097.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Age, sex, degree of dysplasia, prior surgery, primary site, and smoking history did not correlate with symptoms (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>QOL outcomes related to IP resection are largely driven by nasal, sleep, and otologic\/facial subdomains, though patients appear to experience enduring improvement as early as 3\u2009months postoperatively. Recurrent disease is a major driver of negative QOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 135:579\u2013585, 2025\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31725","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T07:55:04Z","timestamp":1724486104000},"page":"579-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quality\u2010of\u2010Life Outcomes Following Endoscopic Resection of Sinonasal Inverted Papilloma"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-1060","authenticated-orcid":false,"given":"Arash","family":"Abiri","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-5662","authenticated-orcid":false,"given":"Katelyn K.","family":"Dilley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-5976","authenticated-orcid":false,"given":"Theodore V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy K.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-3474","authenticated-orcid":false,"given":"Elysia M.","family":"Grose","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-3802","authenticated-orcid":false,"given":"Siddhant H.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4051-9994","authenticated-orcid":false,"given":"Sanjena","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-2067","authenticated-orcid":false,"given":"Jennifer E.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-8287","authenticated-orcid":false,"given":"Jacob G.","family":"Eide","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health System  Detroit Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-2685","authenticated-orcid":false,"given":"Rijul S.","family":"Kshirsagar","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Kaiser Permanente Redwood City Medical Center  Redwood City California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio 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