{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:28:47Z","timestamp":1782865727967,"version":"3.54.5"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To ascertain trends in ototoxicity observed with monoclonal antibodies (mABs) and understand the impact they may have on hearing function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Embase, Scopus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A systematic review was performed following PRISMA guidelines. Data were reviewed for demographics, utilized mABs with respective indication and dosing, audiometric outcomes, and treatment for otologic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 757 studies reviewed, a total of 44 were included, encompassing 18,046 patients treated with mABs. Mean age of the sample was 57.8\u2009years old. The search yielded 18 agents of ototoxicity, with reported symptoms of ototoxicity such as hearing loss, tinnitus, and\/or aural fullness occurring in 1079 of total patients. Main agents causing ototoxicity were teprotumumab (<jats:italic>n<\/jats:italic>\u2009=\u200917\/44 studies), nivolumab (<jats:italic>n<\/jats:italic>\u2009=\u200910\/44), ipilimumab (<jats:italic>n<\/jats:italic>\u2009=\u20099\/44), pembrolizumab (<jats:italic>n<\/jats:italic>\u2009=\u20095\/44), and rituximab (<jats:italic>n<\/jats:italic>\u2009=\u20094\/44). Thirty\u2010one of 44 studies encompassing eight agents reported audiometric data for ototoxic agents, showing sensorineural hearing loss primarily in the high\u2010frequency range. Only two articles performed ultrahigh\u2010frequency audiograms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Monoclonal antibody usage is expanding, but the vast majority of studies lack substantial audiometric data. Where reported, study design and inclusion criteria vary greatly. Future studies would benefit from rigid inclusion of audiometric data, prospective study design, and consideration of formal ototoxicity screening. Otolaryngologists should be aware of the cochlear immune response and potential impact of this expanding medication class on hearing function. <jats:italic>Laryngoscope<\/jats:italic>, 135:491\u2013506, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31763","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:35:29Z","timestamp":1726234529000},"page":"491-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Impact of Monoclonal Antibody Usage on Hearing Outcomes: A Systematic Review"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-6165","authenticated-orcid":false,"given":"Priya","family":"Arya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mercer University School of Medicine  Savannah Georgia U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansy","family":"Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Drexel University College of Medicine  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Quimby","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-0679","authenticated-orcid":false,"given":"Jason A.","family":"Brant","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania U.S.A."},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Corporal Michael J. 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