{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:50:26Z","timestamp":1788792626335,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The prognostic significance of human papillomavirus (HPV) genotypes in oropharyngeal squamous cell carcinoma (OPSCC) has garnered considerable attention due to the increasing reliance on HPV status for clinical decision\u2010making. This study aimed to compare the survival outcomes associated with different HPV genotypes in patients with OPSCC relative to HPV\u2010negative tumors, providing insights into the potential implications for treatment de\u2010intensification strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with invasive OPSCC were included from the National Cancer Database (NCDB). Patients were stratified based on HPV status and genotype, with HPV\u2010negative tumors serving as the reference group. Multivariable Cox regression analysis was performed to assess the independent prognostic value of different HPV genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Th majority of patient were classified as HPV\u2010positive (<jats:italic>N<\/jats:italic>\u2009=\u200917,358, 70.0%), with HPV 16 being the most common genotype (<jats:italic>N<\/jats:italic>\u2009=\u200915410\/17358, 88.8%) compared with other high\u2010risk (<jats:italic>N<\/jats:italic>\u2009=\u20091217\/17,358, 7.0%) and low\u2010risk (<jats:italic>N<\/jats:italic>\u2009=\u2009731\/17,358, 4.2%) HPV genotypes. A significantly lower risk of death was measured for all HPV\u2010positive compared with HPV\u2010negative tumors (HPV 16: adjusted HR 0.51; 95% CI: 0.49\u20130.54; other high\u2010risk HPV: adjusted HR 0.56; 95% CI: 0.49\u20130.63; low\u2010risk HPV: adjusted HR 0.59; 95% CI: 0.50\u20130.68; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the significant prognostic value of HPV genotypes in OPSCC, underscoring the superior survival outcomes of HPV\u2010positive tumors across all genotypes compared with HPV\u2010negative tumors. Detailed HPV subtype analysis can inform better treatment decisions and support de\u2010intensification strategies for patients with low\u2010risk genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 135:695\u2013704, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31775","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T10:26:19Z","timestamp":1726655179000},"page":"695-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Significance of Human Papillomavirus Genotypes in Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7785","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery AdventHealth Orlando  Orlando Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-3589","authenticated-orcid":false,"given":"Jeffery Scott","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery AdventHealth Orlando  Orlando Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uthman","family":"Alamoudi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery AdventHealth Orlando  Orlando Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-5485","authenticated-orcid":false,"given":"Bruce","family":"Haughey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery AdventHealth Orlando  Orlando Florida U.S.A."},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of South Florida Morsani College of Medicine  Tampa Florida U.S.A."},{"name":"Department of Surgery University of Auckland School of Medicine and Allied Health Sciences  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.1804"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.3567"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00603-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21669"},{"key":"e_1_2_6_8_1","unstructured":"National Comprehensive Cancer Network.Head and Neck Cancers (version 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