{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T17:19:33Z","timestamp":1780852773010,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011824","name":"European Academy of Allergy and Clinical Immunology","doi-asserted-by":"publisher","award":["2023 winner"],"award-info":[{"award-number":["2023 winner"]}],"id":[{"id":"10.13039\/501100011824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Sarcoidosis is an inflammatory, non\u2010caseating granulomatous multisystem disease associated with JAK\u2010STAT (Janus kinases\u2010signal transducer and activator of transcription proteins) pathway activation. We present a patient with severe multi\u2010systemic sarcoidosis who showed marked improvement with tofacitinib with regards to pulmonary, cutaneous, nasal and laryngeal disease. Tofacitinib prevented critical laryngeal stenosis from progressing to tracheostomy, induced regression of cutaneous lesions and improved pulmonary function in this steroid\u2010resistant and immunosuppressive intolerant case. This case report supports further the role of JAK\u2010inhibitors in the treatment of systemic sarcoidosis. <jats:italic>Laryngoscope<\/jats:italic>, 135:829\u2013832, 2025<\/jats:p>","DOI":"10.1002\/lary.31778","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T07:55:11Z","timestamp":1726732511000},"page":"829-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>JAK<\/scp>\u2010inhibitor Tofacitinib in Severe Laryngeal Sarcoidosis: A Case Report"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-6300","authenticated-orcid":false,"given":"Meryem","family":"Demir","sequence":"first","affiliation":[{"name":"Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust  London UK"},{"name":"Internal Medicine, Allergy and Clinical Immunology Ege University Faculty of Medicine  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Kouranos","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostadin","family":"Stoenchev","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Durham","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy W","family":"Scadding","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Morar","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital, NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadwan","family":"Al Yaghchi","sequence":"additional","affiliation":[{"name":"National Centre for Airway Reconstruction, Charing Cross Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guri S","family":"Sandhu","sequence":"additional","affiliation":[{"name":"National Centre for Airway Reconstruction, Charing Cross Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Saleh","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust  London UK"},{"name":"Rhinology and Imperial Facial Reconstruction Centres, Charing Cross Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"187","article-title":"The promise of JAK inhibitors for treatment of sarcoidosis and other inflammatory disorders with macrophage activation","volume":"93","author":"Wang A","year":"2020","journal-title":"Rev Lit"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13814"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00199-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13679"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30615-x"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:05:56Z","timestamp":1736748356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/lary.31778"],"URL":"https:\/\/doi.org\/10.1002\/lary.31778","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"assertion":[{"value":"2024-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}