{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:49:12Z","timestamp":1772610552627,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare survival endpoints in patients with laryngeal carcinoma in situ (L\u2010CIS) who received definitive radiotherapy (RT) versus other modalities as first\u2010line treatment and after disease recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study of patients with L\u2010CIS treated between June 2001 and December 2021. Survival outcomes (recurrence\u2010free (RFS), invasion\u2010free (IFS), laryngectomy\u2010free (LFS), and overall survival (OS)) were compared between patients who had first\u2010line RT versus non\u2010RT modalities and for patients with recurrent disease who underwent second\u2010line RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 85 patients with L\u2010CIS were included (73 men [85.9%] and 12 [14.1%] women, median age of 65 [IQR: 55\u201374] years). Of these, 42 had first\u2010line RT (49.4%) and 43 (50.6%) had non\u2010RT treatment. After median follow\u2010up of 4.8 (IQR: 2.8\u20139) years, patients in the first\u2010line RT group had improved 2\u2010year (94.2% [95% confidence interval (CI): 86.7\u2013100] versus 41.7% [CI: 29.3\u201359.5]) and 5\u2010year (90.6% [CI: 80.9\u2013100] versus 27.5% [CI: 16.4\u201348.2]) RFS relative to non\u2010RT recipients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). OS and IFS were similar between groups. However, patients in the RT group had worse 2\u2010year (94% [CI: 87\u2013100] versus 98% [CI: 93\u2013100]) and 5\u2010year (82% [CI: 68\u201399] versus 98% [CI: 93\u2013100]; <jats:italic>p<\/jats:italic>\u2009=\u20090.013) LFS. All 35 patients with recurrent L\u2010CIS were successfully cured with second\u2010line treatments (12 received RT [34.3%]), and no differences in any survival endpoints were seen in these patients based on first\u2010line and second\u2010line treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although first\u2010line RT for L\u2010CIS led to improved recurrence\u2010free survival compared with other modalities, second\u2010line RT may be a particularly valuable option for recurrent CIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 135:779\u2013786, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31786","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T07:14:14Z","timestamp":1727334854000},"page":"779-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment Outcomes in Patients with Carcinoma In Situ of the Larynx"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6763","authenticated-orcid":false,"given":"Ahmed","family":"I Ghanem","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Henry Ford Health\u2010Cancer  Detroit Michigan U.S.A."},{"name":"Clinical Oncology Department, Faculty of Medicine University of Alexandria  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Henry Ford Health\u2010Cancer  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-340X","authenticated-orcid":false,"given":"Christian E","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glendon M","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-4737","authenticated-orcid":false,"given":"Ross","family":"Mayerhoff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Henry Ford Health\u2010Cancer  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01405-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb00948.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790480022006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0385-8146(98)00041-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-8140(02)00073-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00881-w"},{"key":"e_1_2_7_8_1","unstructured":"National Comprehensive Cancer Network.NCCN 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