{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:45:06Z","timestamp":1790729106920,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>To report a case of a patient undergoing GLP\u20101 receptor agonist therapy in which increased FDG uptake in brown adipose tissue (BAT) mimicked metastatic head and neck cancer on PET\/CT imaging. A 61\u2010year\u2010old female with Class III obesity presented with a right\u2010sided neck mass after significant weight loss following the use of the GLP\u20101 receptor agonist, Semaglutide. PET\/CT revealed FDG uptake in the right level II lymph node and extensive BAT uptake throughout the neck and mediastinum, complicating the diagnosis. Increased FDG uptake in the cervical and supraclavicular BAT regions led to diagnostic confusion, mimicking diffuse regional metastasis. Careful interpretation of PET\/CT imaging, with fusion of anatomical and functional data, was essential to differentiate hypermetabolic BAT from malignant disease. Increased BAT FDG uptake, particularly in patients using GLP\u20101 receptor agonists, can complicate the evaluation of head and neck cancer. Awareness of this interaction is critical to avoid misdiagnosis and overtreatment. <jats:italic>Laryngoscope<\/jats:italic>, 135:741\u2013743, 2025<\/jats:p>","DOI":"10.1002\/lary.31815","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:49:04Z","timestamp":1728290944000},"page":"741-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Brown Adipose Tissue Mimicking Head and Neck Cancer on <scp>PET<\/scp> Scan in a Patient on <scp>GLP<\/scp>\u20101 Drug"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9077-2141","authenticated-orcid":false,"given":"Daron B.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa L.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Oregon Health &amp; Science University  Portland Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-6721","authenticated-orcid":false,"given":"James B.","family":"Tansey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Nedzi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Makowski","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."},{"name":"Center for Cancer Research University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.N.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."},{"name":"Center for Cancer Research University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Methodist Le Bonheur Healthcare, Memphis Radiological PC  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0325-5637","authenticated-orcid":false,"given":"John P.","family":"Gleysteen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Tennessee Health Science Center College of Medicine  Memphis Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810780"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.12.016"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108592"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-014-0349-x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154167"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:06:38Z","timestamp":1736748398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/lary.31815"],"URL":"https:\/\/doi.org\/10.1002\/lary.31815","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"2024-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}