{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:38:58Z","timestamp":1790804338525,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Objective(s)<\/jats:title><jats:p>To determine the accuracy of conventional and diffusion\u2010weighted (DWI) MRI for the differential diagnosis between mucopyocele and mucocele using surgical diagnosis as a reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included patients referred to our institution between March 2017 and February 2024 for paranasal sinus MRI to characterize an expansile non\u2010enhanced sinus filling on CT. The T1 and T2 signal intensities were recorded, as well as the presence of restriction diffusion, of the penumbra sign, the double rim sign, and the presence of parietal micro\u2010abscesses. Quantitative apparent diffusion coefficient values were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 74 patients aged 18 to 88\u2009years (mean age: 60.4\u2009\u00b1\u200917.7\u2009years). Of these, 43 had a mucopyocele and 31 had a mucocele. The T1 high signal intensity was different amongst groups as an hypersignal was present in 35.5% of mucoceles and only 4.7% of mucopyoceles (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). The T2 signal did not differ between the two groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.59). The double rim sign and the presence of parietal micro\u2010abscesses demonstrated 96.8% and 100% specificities, respectively, but were predominantly located in the maxillary sinus. The penumbra sign exhibited a sensitivity of 60.5% and a specificity of 67.7%. All mucopyoceles exhibited a diffusion restriction with an apparent diffusion coefficient of less than 0.78\u2009\u00d7\u200910\u20133\u2009mm<jats:sup>2<\/jats:sup>\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DWI is the most useful MRI tool for the accurate differential diagnosis between mucopyocele and mucocele in non\u2010enhanced sinus fillings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 (case\u2013control study) <jats:italic>Laryngoscope<\/jats:italic>, 135:1008\u20131014, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31833","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T09:39:28Z","timestamp":1728898768000},"page":"1008-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion\u2010Weighted <scp>MRI<\/scp> Over Standard <scp>MRI<\/scp> for Differential Diagnosis between Mucopyocele and Mucoceles"],"prefix":"10.1002","volume":"135","author":[{"given":"Vanessa","family":"Adewole","sequence":"first","affiliation":[{"name":"ENT and Head and Neck Surgery Department University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Boubaker","sequence":"additional","affiliation":[{"name":"Guilloz Imaging Department, Central Hospital University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Hossu","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, IADI  Nancy France"},{"name":"Universit\u00e9 de Lorraine, CIC, Innovation Technologique, University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Surgery Department University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Blum","sequence":"additional","affiliation":[{"name":"Guilloz Imaging Department, Central Hospital University Hospital Center of Nancy  Nancy France"},{"name":"Universit\u00e9 de Lorraine, INSERM, IADI  Nancy France"},{"name":"Universit\u00e9 de Lorraine, CIC, Innovation Technologique, University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Gondim Teixeira","sequence":"additional","affiliation":[{"name":"Guilloz Imaging Department, Central Hospital University Hospital Center of Nancy  Nancy France"},{"name":"Universit\u00e9 de Lorraine, INSERM, IADI  Nancy France"},{"name":"Universit\u00e9 de Lorraine, CIC, Innovation Technologique, University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-8958","authenticated-orcid":false,"given":"C\u00e9cile","family":"Rumeau","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Surgery Department University Hospital Center of Nancy  Nancy France"},{"name":"Universit\u00e9 de Lorraine, DevAh  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1350-1694","authenticated-orcid":false,"given":"Romain","family":"Gillet","sequence":"additional","affiliation":[{"name":"Guilloz Imaging Department, Central Hospital University Hospital Center of Nancy  Nancy France"},{"name":"Universit\u00e9 de Lorraine, INSERM, IADI  Nancy France"},{"name":"Universit\u00e9 de Lorraine, CIC, Innovation Technologique, University Hospital Center of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"57","article-title":"Sphenoidal mucopyocele with visual impairment: case report of a rare disease and literature review","volume":"1","author":"Gyawali BR","year":"2018","journal-title":"Rhinology"},{"issue":"1","key":"e_1_2_6_3_1","article-title":"Mucopyocele of the maxillary sinus","volume":"11","author":"Kshar A","year":"2014","journal-title":"Dent Res 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