{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:32Z","timestamp":1786978112845,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Topical nasal decongestants (TNDs) are used to reduce nasal soft tissue edema and obstruction. However, after frequent TND use, patients can develop rhinitis medicamentosa (RM) with rebound nasal edema and obstruction. Management of RM has centered largely on TND cessation\u2009\u00b1\u2009intranasal corticosteroids. The purpose of this study was to compare nasal obstruction outcomes following nasal obstruction surgery in patients with versus without RM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective case\u2013control study was conducted with adult patients who underwent bilateral inferior turbinate reduction (ITR) with or without septoplasty and nasal valve repair. Patients with versus without RM were assessed. RM was defined as at least daily TND use for \u22654\u2009weeks. Preoperative and postoperative Nasal Obstruction Symptom Evaluation (NOSE) scores, and long\u2010term TND cessation rates were collected. NOSE score changes were compared between patients with versus without RM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 36 RM patients, mean age was 52.0\u2009years, and 63.9% were male. Of 116 non\u2010RM patients, mean age was 41.6\u2009years, and 46.6% were male. Postoperative NOSE scores were collected at a mean 972.1\u2009days postoperatively for RM patients, and 565.0\u2009days for non\u2010RM patients. Mean NOSE score reductions were\u2009\u2212\u20099.8 for RM and\u2009\u2212\u20098.6 for non\u2010RM patients, both of which were significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). NOSE score reductions were not significantly\u00a0between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.2438). Long\u2010term TND cessation was maintained in 86.1% of RM patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with and without RM achieved similar long\u2010term significant NOSE score reductions following nasal obstruction surgery, and 86.1% of RM patients maintained long\u2010term TND cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 135:1015\u20131020, 2025\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31839","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:32:39Z","timestamp":1728556359000},"page":"1015-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes after Functional Nasal Surgery in Patients with Versus without Rhinitis Medicamentosa"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-1775","authenticated-orcid":false,"given":"Anthony P.","family":"Di Ponio","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Nadim","family":"Samad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pellizzari","sequence":"additional","affiliation":[{"name":"Michigan State University College of Human Medicine  East Lansing Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Mackie","sequence":"additional","affiliation":[{"name":"Michigan State University College of Human Medicine  East Lansing Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-9920","authenticated-orcid":false,"given":"Robert H.","family":"Deeb","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-4782","authenticated-orcid":false,"given":"John R.","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Henry Ford Health  Detroit Michigan U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504010-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2007.06.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454309"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300216"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00805.x"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"153","article-title":"The cholinergic innervation of the human nasal mucosa. A histochemical study","volume":"32","author":"Ishii T","year":"1970","journal-title":"Pract Otorhinolaryngol (Basel)"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00302192"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1701OC"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275642"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(99)80053-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.08.025"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050000309"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300213"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209128948"},{"issue":"1","key":"e_1_2_7_16_1","first-page":"9","article-title":"Long\u2010term use of oxy\u2010 and xylometazoline nasal sprays induces rebound swelling, tolerance, and nasal hyperreactivity","volume":"34","author":"Graf P","year":"1996","journal-title":"Rhinology"},{"issue":"3","key":"e_1_2_7_17_1","first-page":"233","article-title":"Predisposing factors of rhinitis medicamentosa: what can influence drug discontinuation?","volume":"58","author":"De Corso E","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897782537197"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"14","article-title":"Sustained use of xylometazoline nasal spray shortens the decongestive response and induces rebound swelling","volume":"33","author":"Graf P","year":"1995","journal-title":"Rhinology"},{"issue":"3","key":"e_1_2_7_20_1","first-page":"167","article-title":"Oxymetazoline nasal spray three times daily for four weeks in normal subjects is not associated with rebound congestion or tachyphylaxis","volume":"41","author":"Watanabe H","year":"2003","journal-title":"Rhinology"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.117717"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00744.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3199"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23287"},{"issue":"3","key":"e_1_2_7_25_1","first-page":"148","article-title":"Rhinitis medicamentosa","volume":"16","author":"Ramey JT","year":"2006","journal-title":"J Invest Allergol Clin Immunol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419880576"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818807891"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2012.09.005"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21574"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924231185727"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414526694"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.161"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000106"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23094"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T01:07:06Z","timestamp":1739754426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/lary.31839"],"URL":"https:\/\/doi.org\/10.1002\/lary.31839","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}