{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:02:11Z","timestamp":1739854931099,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the relative 5\u2010year overall survival (OS) and 5\u2010year recurrence\u2010free survival (RFS) outcomes for adjuvant interferon therapy in the treatment of head and neck cutaneous melanoma (HNCM) with parotid gland involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted at a single tertiary care institution to analyze patients undergoing parotidectomy for cutaneous head and neck melanoma involving the parotid gland from 2000 to 2014. Time\u2010to\u2010event analyses were performed using Kaplan\u2013Meier curves with log\u2010rank <jats:italic>p<\/jats:italic>\u2010values and Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample consisted of 82 patients who underwent surgical resection of stage III HNCM with parotid involvement. The mean follow\u2010up was 67.8\u2009months (SD 65) after diagnosis. Twenty\u2010one patients received adjuvant interferon therapy, 12 patients received adjuvant radiation therapy, and 49 patients received no adjuvant therapy. Crude 5\u2010year OS rates were 95.0% for interferon therapy, 33.3% for adjuvant RT, and 40.4% for no adjuvant therapy. Crude 5\u2010year RFS rates were 75.2%, 19.5%, and 40.8% respectively. In the fully adjusted model, adjuvant interferon therapy was associated with improved 5\u2010year OS compared to adjuvant RT (HR 0.10, 95% CI 0.011\u20130.837; <jats:italic>p<\/jats:italic>\u2009=\u20090.034). There was no significant association between adjuvant interferon therapy and 5\u2010year RFS in the fully adjusted model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjuvant interferon therapy for surgically resected stage III cutaneous melanoma with parotid gland involvement may be associated with improved survival outcomes. These findings support the growing evidence for the use of immunotherapy in melanoma, and potentially a unique role for when melanoma involves the lymphatic\u2010rich parotid gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 135:1098\u20131104, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31854","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T07:41:52Z","timestamp":1729150912000},"page":"1098-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Adjuvant Interferon Therapy on Survival Outcomes for Cutaneous Melanoma With Parotid Involvement"],"prefix":"10.1002","volume":"135","author":[{"given":"Erin","family":"Kim","sequence":"first","affiliation":[{"name":"University of Michigan Medical School  Ann Arbor Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Raven","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Wayne State University  Detroit Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-6663","authenticated-orcid":false,"given":"Nicholas R.","family":"Lenze","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Michigan  Ann Arbor Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-4960","authenticated-orcid":false,"given":"Janice L.","family":"Farlow","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Indiana University  Indianapolis Indiana U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Michigan  Ann Arbor Michigan U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"volume-title":"Cancer Treatment & Survivorship Facts & Figures 2022\u20132024","year":"2022","author":"American Cancer Society","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2021.06.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1112"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01458-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-22-0266"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02575"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0666-x"},{"volume-title":"Melanoma: Cutaneous","year":"2024","author":"National Comprehensive Cancer Network","key":"e_1_2_6_10_1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24810"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000182"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709030"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802357"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21404"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-005-1319-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.052"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06965.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022449613907"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2017-CT073"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211007442"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4356-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00431-9"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T06:06:33Z","timestamp":1739772393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/lary.31854"],"URL":"https:\/\/doi.org\/10.1002\/lary.31854","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"2024-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}