{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:31:30Z","timestamp":1747150290034,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>The Burkholderia cepacia complex (BCC) is a rare pathogen typically causing respiratory illnesses in immunocompromised individuals. We present a novel case of BCC manifesting as a laryngeal abscess, mimicking a laryngeal malignancy in an immunocompetent patient. A 74\u2010year\u2010old male presented to the emergency department with acute respiratory failure and was emergently intubated, revealing abnormal supraglottic tissue. ENT consultation post\u2010extubation and flexible laryngoscopy suggested malignancy in the right supraglottis. A subsequent CT neck showed an expansive paraglottic mass, again consistent with an advanced malignancy. During direct laryngoscopy with biopsy, purulence was encountered, and cultures were obtained. Biopsy results showed benign mucosa with inflammation, and cultures identified BCC. The patient received 7\u2009days of Levofloxacin and Ampicillin\u2010Sulbactam before culture results. Follow\u2010up 2\u2009weeks later showed near\u2010complete symptom resolution, normal supraglottic mucosa on flexible laryngoscopy, and interval CT neck showed resolution of the \u201cmass.\u201d This case involves an unusual presentation of an acute paraglottic BCC infection initially mistaken for a laryngeal mass. BCC is typically a threat to individuals with cystic fibrosis (CF) or other immunocompromised states due to its intrinsic antibiotic resistance. However, BCC is rarely implicated in paraglottic infections or abscess formation. This is the first reported case of a laryngeal BCC infection mimicking a laryngeal mass. It underscores the importance of maintaining an open differential diagnosis until pathologic confirmation, even when imaging and clinical examination suggest malignancy. <jats:italic>Laryngoscope<\/jats:italic>, 135:1419\u20131422, 2025<\/jats:p>","DOI":"10.1002\/lary.31869","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:17:54Z","timestamp":1730139474000},"page":"1419-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Case of Paraglottic Burkholderia Cepacia Complex Infection Mimicking a Laryngeal Malignancy"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0312-9047","authenticated-orcid":false,"given":"James A.","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Alabama at Birmingham  Birmingham Alabama U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0512-9195","authenticated-orcid":false,"given":"Harrison","family":"Reeves","sequence":"additional","affiliation":[{"name":"Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Rivers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Alabama at Birmingham  Birmingham Alabama U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Panuganti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Alabama at Birmingham  Birmingham Alabama U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.07.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26359"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000221347.42120.f8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181e538d8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894221115757"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:25:26Z","timestamp":1741839926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/lary.31869"],"URL":"https:\/\/doi.org\/10.1002\/lary.31869","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}