{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:51:36Z","timestamp":1788454296164,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3P0351"],"award-info":[{"award-number":["CMRPG3P0351"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Severe type 2 eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is challenging to treat and susceptible to recurrence post\u2010surgery. This study aimed to evaluate the relationship between clinical markers and tissue type 2 inflammatory severity in patients with CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients who underwent endoscopic sinus surgery for bilateral CRSwNP were prospectively enrolled. Tissue eosinophil count (TEC) was evaluated. Expression levels of type 2 cytokines, including IL\u20105 and IL\u201013, in nasal polyps were determined using real\u2010time PCR. Correlations between clinical markers and tissue type 2 inflammation were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 150 participants were recruited. Ninety\u2010five (63.3%) exhibited type 2 eosinophilic CRSwNP defined by TEC \u226510\/high power field. Weak to moderate correlations were observed between clinical and tissue markers of type 2 inflammation. Among the clinical markers, blood eosinophil count (BEC) exhibited the highest correlation with tissue type 2 inflammatory severity, as determined by TEC, IL\u20105, and IL\u201013 expression levels in nasal polyps. Comorbid asthma, nonsmoking status, ethmoid\/maxillary sinuses (E\/M) ratio, and BEC were significant predictors of eosinophilic CRSwNP in the regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BEC, a dominant clinical marker, exhibits the highest correlation with tissue type 2 inflammatory severity, as determined by TEC, IL\u20105, and IL\u201013 in nasal polyps. Comorbid asthma, nonsmoking status, E\/M ratio, and BEC were significant predictors of eosinophilic CRSwNP. This could help clinicians better evaluate the severity of type 2 inflammation in patients with CRSwNP and provide optimal therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 135:1326\u20131334, 2025\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31899","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:48:34Z","timestamp":1732682914000},"page":"1326-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Blood Eosinophil Count is the Dominant Clinical Marker for type 2 Inflammatory Severity in\n                    <scp>CRSwNP<\/scp>"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-9633","authenticated-orcid":false,"given":"Pei\u2010Wen","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Che","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-6209","authenticated-orcid":false,"given":"Po\u2010Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otolaryngology Xiamen Chang Gung Hospital  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsi","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4188-3498","authenticated-orcid":false,"given":"Chien\u2010Chia","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University  Taoyuan 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