{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:13:47Z","timestamp":1782425627169,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although nasopharynx cancer (NPC) is rare in the United States, global epidemiology varies greatly. Therefore, understanding NPC disparities in the diverse US setting is critical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Data from the National Cancer Database (NCDB, 2004\u20102021) identified patients with NPC; NCDB allows disaggregation by Asian American (AA) subgroups. Multivariable ordinal logistic regression adjusting for demographic and socioeconomic factors defined adjusted odds ratios (aORs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 15,862 patients, 11,173 (70.4%) were male (median age 59). Commonest groups included 10,034 (63.3%) White, 2,272 (14.3%) Black, 1,103 (7.0%) Chinese, 442 (2.8%) Filipino, and 338 (2.1%) Vietnamese patients. Prior to disaggregation, the proportion of stage IV disease at presentation was 43.2% among White (ref), 50.0% among Black (aOR 1.12, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), 52.0% among Native American (aOR 1.18, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), 41.9% among AA (aOR 0.97, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), and 55.1% among Native Hawaiian and Other Pacific Islander patients (aOR 1.47, <jats:italic>p<\/jats:italic>\u2009=\u20090.021).<\/jats:p><jats:p>Upon disaggregation, the proportion of stage IV disease was the greatest (&gt;50%) among Black (50.0%, aOR 1.12, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), Laotian (61.5%, aOR 2.21, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), Hmong (73.2%, aOR 2.92, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and Other Pacific Islander patients (60.9%, aOR 1.83, <jats:italic>p<\/jats:italic>\u2009=\u20090.004); 44.2% of Filipino patients also presented with stage IV disease (aOR 1.21, <jats:italic>p<\/jats:italic>\u2009=\u20090.033). Odds of presenting with advanced stage disease were lower among Chinese patients (35.7% stage IV, aOR 0.72, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although most NPC patients were Chinese, White, or Black, stage IV disease at presentation was most common among Hmong, Laotian, non\u2010Hawaiian Pacific Islander, and Black patients. Efforts are needed to improve awareness of NPC among less canonically affected groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 135:1113\u20131119, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31907","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T11:10:42Z","timestamp":1731755442000},"page":"1113-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nasopharynx Cancer in the <scp>United States<\/scp>: Racial and Ethnic Disparities in Stage at Presentation"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6119-0889","authenticated-orcid":false,"given":"Edward Christopher","family":"Dee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wang","sequence":"additional","affiliation":[{"name":"Harvard College  Cambridge Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances Dominique V.","family":"Ho","sequence":"additional","affiliation":[{"name":"College of Medicine University of the Philippines Manila  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshal R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Lapen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tej A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Healthcare Management and Policy University of Pennsylvania  Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin Jay G.","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Department of Medicine, NYC Health + Hospitals\/Elmhurst Icahn School of Medicine at Mount Sinai  Queens New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1702"},{"key":"e_1_2_6_3_1","unstructured":"Nasopharyngeal Cancer Survival Rates|American Cancer Society. 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