{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:10:36Z","timestamp":1788246636672,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systemic review with meta\u2010analysis evaluated the effect of intranasal BTX\u2010A turbinate injection on chronic rhinitis\u2010related symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>We reviewed studies retrieved from databases up to Aug 2024. The studies evaluating the degree of change of rhinitis\u2010related symptom scores and quality of life before and after BTX\u2010A injection were analyzed. Standard mean differences were used to calculate effect sizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 269 patients from 7 studies were analyzed. BTX\u2010A injection showed a significant improvement in rhinitis\u2010related symptoms (congestion: 2.5416, 95% CI 1.0927\u20133.9905,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200994.4%, itching: 1.2553, 95% CI 0.6660\u20131.8446;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200970.8%, rhinorrhea: 1.8451, 95% CI 1.0468\u20132.6435,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200989.7%, and sneezing: 1.3580, 95% CI 0.5194\u20132.1967;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200990.7%), total nasal symptom score (2.4020, 95% CI 1.4161\u20133.3879,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200986.1%), and quality of life (1.5256, 95% CI 1.0760\u20131.9752;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%) throughout the follow\u2010up period (4\u2009months). However, 3\u2009months after injection, although symptom improvement remained, there was no statistical significance. Allergic rhinitis (AR) patients showed a significant improvement in rhinitis\u2010related symptoms compared with nonallergic rhinitis (NAR) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Nasal symptoms and quality of life scores related to rhinitis were decreased after BTX\u2010A injection. In particular, this treatment showed better efficacy in AR and could be more beneficial for the symptoms of nasal congestion and rhinorrhea at the early periods of treatment. However, the effects lasted for a relatively short period of only 2\u20133\u2009months.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 135:1545\u20131552, 2025\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31936","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T07:05:04Z","timestamp":1733209504000},"page":"1545-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Turbinate Injection of Botulinum Toxin in the Treatment of the Chronic Rhinitis"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-5572","authenticated-orcid":false,"given":"Do H.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University School of Medicine  Durham North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-7820","authenticated-orcid":false,"given":"Se H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.06.049"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0108-1675.2004.00389.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino.11.152"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143183"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAO.0b013e318196ca1e"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40521-020-00243-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0898-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200011000-00012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.11.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0636-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26616"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3295"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.07.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.2.143"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2008.03.023"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.18787\/jr.2024.00015"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924241251387"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100158281"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2003.11720744"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.06.031"},{"key":"e_1_2_6_24_1","first-page":"45","article-title":"Investigation of the effects of intranasal botulinum toxin type A and ipratropium bromide nasal spray on nasal hypersecretion in idiopathic rhinitis without eosinophilia","volume":"46","author":"Sapci T","year":"2008","journal-title":"Rhinology"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-OA-0510"},{"key":"e_1_2_6_26_1","first-page":"400","article-title":"Septal injection in comparison with inferior turbinates injection of botulinum toxin a in patients with allergic rhinitis","volume":"18","author":"Abtahi SM","year":"2013","journal-title":"J Res Med 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