{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:03:47Z","timestamp":1788829427969,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the most effective treatment modality for achieving favorable outcomes in early glottic tumors with anterior commissure involvement (ACI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Embase, Web of Science, and ScienceDirect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Random\u2010effects proportional meta\u2010analysis model is used to evaluate the oncological and functional outcomes of transoral laser microsurgery (TLM) versus radiation therapy (RT) in early glottic (T1\u2013T2) cancer with ACI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 736 studies, 40 studies were included, comprising 2666 early glottic tumor patients with ACI. TLM (52%) and upfront RT (48%) were the primary treatment groups. TLM had better 5\u2010year overall survival (OS) (84.5% [80.3%\u201388.0%] vs. 79.4% [75.7%\u201382.7%]). Similarly, TLM\u2010treated patients had better 3\u2010year pooled disease\u2010free survival (DFS) compared with RT\u2010treated patients (82.7% [77.1%\u201387.1%] vs. 73.3% [23.8%\u201396.0%]). TLM exhibited a better 5\u2010year local control rate (LCR) than RT (77.2% vs. 71.6%). In our temporal analysis, TLM had a higher 5\u2010year LCR than RT (78.2% vs. 63.5%) in 2001\u20132012, with similar rates in 2013\u20132024 (76.8% vs. 78.4%). TLM\u2010treated patients had higher laryngeal preservation rates compared with RT patients (93% [90.6%\u201394.8%] vs. 87.6% [82.8%\u201391.2%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis is the first in the literature to compare the outcomes between TLM and RT\u2010treated patients with ACI in early glottic tumors. TLM\u2010treated patients appear to have superior 5\u2010year OS and laryngeal preservation compared with upfront RT\u2010treated patients. However, both TLM and RT exhibited comparable oncological outcomes in early glottic tumor patients with ACI during the recent period from 2013 to 2024. <jats:italic>Laryngoscope<\/jats:italic>, 135:1861\u20131871, 2025<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32005","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T08:39:22Z","timestamp":1736584762000},"page":"1861-1871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>Transoral Laser Microsurgery<\/scp> Versus Radiotherapy for <scp>T1<\/scp>\u2013<scp>T2<\/scp> Glottic Cancer with Anterior Commissure Involvement: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-1658","authenticated-orcid":false,"given":"Srivatsa Surya","family":"Vasudevan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Louisiana State University Health Sciences Center  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Bryan","sequence":"additional","affiliation":[{"name":"Louisiana State University Health School of Medicine  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Ericksen","sequence":"additional","affiliation":[{"name":"Louisiana State University Health School of Medicine  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Alla","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Louisiana State University Health Sciences Center  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-8746","authenticated-orcid":false,"given":"Ameya A.","family":"Asarkar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Louisiana State University Health Sciences Center  Shreveport Louisiana U.S.A."},{"name":"Department of Surgery Overton Brooks Veterans Administration Medical Center  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Olinde","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Louisiana State University Health Sciences Center  Shreveport Louisiana U.S.A."},{"name":"Department of Surgery Overton Brooks Veterans Administration Medical Center  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Willis\u2010Knighton Cancer Center  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-318X","authenticated-orcid":false,"given":"Cherie\u2010Ann O.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Louisiana State University Health Sciences Center  Shreveport Louisiana U.S.A."},{"name":"Department of Surgery Overton Brooks Veterans Administration Medical Center  Shreveport Louisiana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Head and Neck Cancers: Symptoms & Treatment. 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