{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:38:05Z","timestamp":1774463885307,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n \n Hypoglossal nerve stimulation (HGNS) is an effective surgical treatment for many patients with moderate\u2010to\u2010severe obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure. Patients with neuromuscular disorders (NMD) are particularly vulnerable to more complex sleep\u2010related breathing disorders due to respiratory muscle weakness and the associated risk of hypoventilation.<\/jats:p>\n \n In this study, we present five patients with myasthenia gravis (\n n<\/jats:italic>\n \u2009=\u20092), muscular dystrophy, Charcot\u2010Marie\u2010Tooth, and advanced multiple sclerosis who underwent HGNS therapy for OSA.\n <\/jats:p>\n \n At time of surgery, the mean patient age was 54\u2009\u00b1\u200918.7\u2009years and mean BMI was 24.6\u2009\u00b1\u20094.6 kg\/m\n 2<\/jats:sup>\n . Mean device adherence was 8\u2009\u00b1\u20091.1\u2009h\/night at three months and 7.2\u2009\u00b1\u20091.7\u2009h\/night at 12 months. Mean apnea\u2010hypopnea index (AHI) improved significantly from preoperative baseline (34.9 to 8.5,\n p<\/jats:italic>\n \u2009=\u20090.03) and 5\/6 patients had a postoperative AHI <5. Epworth Sleepiness Scale scores significantly improved postoperatively (13.1\u20138.5,\n p<\/jats:italic>\n \u2009=\u20090.03). Oxygen nadir trended upward (75.5\u201385.3,\n p<\/jats:italic>\n \u2009=\u20090.84).\n <\/jats:p>\n \n Our limited findings demonstrate that HGNS was a safe and effective treatment for five patients with OSA and comorbid NMD. Prospective studies and larger sample sizes are warranted to support our findings and confirm whether HGNS is a potential therapeutic option for this unique patient population.\n Laryngoscope<\/jats:italic>\n , 135:2631\u20132633, 2025\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.32050","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T06:43:21Z","timestamp":1739601801000},"page":"2631-2633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea and Comorbid Neuromuscular Disorders"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-7271","authenticated-orcid":false,"given":"Alison Y.","family":"Choi","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-6806","authenticated-orcid":false,"given":"Thomas M.","family":"Kaffenberger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh Medical Center Pittsburgh Pennsylvania U.S.A."},{"name":"Veterans Affairs Pittsburgh Healthcare System Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Soose","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh Medical Center Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel L.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh Medical Center Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18041642"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2224CI"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.566"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2018.04.006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.11452"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T05:31:44Z","timestamp":1763098304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/lary.32050"],"URL":"https:\/\/doi.org\/10.1002\/lary.32050","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]},"assertion":[{"value":"2024-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}