{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:47:43Z","timestamp":1792032463789,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>With the increasing use of GLP\u20101 receptor agonist (GLP\u20101 RA) drugs for weight loss and diabetes management, concerns have been raised regarding their potential side effects. We aim to assess the frequency of otolaryngologic adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective analysis of national registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Food and Drug Administration's Adverse Event Reporting System (FAERS) database was queried for events related to the GLP\u20101 RA: exenatide, liraglutide, dulaglutide, semaglutide, and tirzepatide from 1\u2009year after their approval until the end of 2023. AEs were collected and sub\u2010stratified according to anatomic site. Reporting odds ratios (ROR) and proportional reporting ratios (PRR) were determined for all AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of AEs reported from all drugs within this study totaled 9,746. Significant signal ratios were defined as a PRR\u22652 and a lower CI ROR &gt;1. Medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) had the highest signals and were significant in virtually all medications. This was followed by GERD which also had very high signal ratios and was significant in all drugs assessed. Semaglutide also had significant signals in anosmia, dry mouth, dysgeusia, and Bell's palsy. Liraglutide had significance in both signals in dysphonia, dysgeusia, tinnitus, and Bell's palsy. This was followed by exenatide which also included dysgeusia and hearing disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RA were associated with various otolaryngologic AEs, with significant signals observed for semaglutide and liraglutide. GERD, MTC, and PTC were of significance in all GLP\u20101 RA in this study. Monitoring these AEs is recommended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 135:2291\u20132298, 2025\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32061","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T06:19:41Z","timestamp":1739341181000},"page":"2291-2298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Otolaryngologic Side Effects of\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5507-2916","authenticated-orcid":false,"given":"Faizaan I.","family":"Khan","sequence":"first","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Guadarrama\u2010Sistos","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-2725","authenticated-orcid":false,"given":"Zain","family":"Mehdi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isuru","family":"Somawardana","sequence":"additional","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Dongre","sequence":"additional","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-098X","authenticated-orcid":false,"given":"Samuel","family":"Razmi","sequence":"additional","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-1938","authenticated-orcid":false,"given":"Keyvon","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Shenoi","sequence":"additional","affiliation":[{"name":"Texas A&amp;M School of Engineering Medicine  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najm","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-7662","authenticated-orcid":false,"given":"Aatin","family":"Dhanda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar G.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Houston Methodist Hospital  Houston Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Medications containing semaglutide marketed for type 2 diabetes or weight loss. 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