{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T05:34:27Z","timestamp":1763098467169,"version":"3.45.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acquired laryngotracheal stenosis (LTS) is notorious for recurrence and the need for repeated procedures to achieve a satisfactory outcome. This limitation is, at least partly, due to the suboptimal healing process of the airway following trauma. Consequently, innovative interventions are required to improve wound healing, which would reflect on improving the outcome of the management of LTS. The objective of this study is to examine the effect of the application of BM\u2010MSCs in preventing subglottic acute stenosis following trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four Sprague\u2013Dawley rats were divided into three equal groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098): two intervention groups and one control group. Subglottic trauma was performed in the three groups. In the intervention groups, bone marrow\u2010derived mesenchymal stem cells (BM\u2010MSCs) were applied either systemically (TS group) or via local injection (TL group). Subglottic specimens from the three groups were compared by histopathological appearance, lamina propria (LP) thickness, and luminal anteroposterior (AP) diameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An intense inflammatory reaction was observed in the control specimens, while a mild inflammatory reaction was detected in the two intervention groups. The LP thickness and the AP diameter were significantly different between the control group and the two intervention groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the present animal model, stem cell application, either systemic or local application, can mitigate subglottic inflammation and stenosis after trauma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32070","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:19:26Z","timestamp":1739776766000},"page":"2437-2444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Application of Bone Marrow Mesenchymal Stem Cells After Subglottic Injury: Animal Study"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-9836","authenticated-orcid":false,"given":"Ezzeldin","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Hazem","family":"Gaafar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radwa Ali","family":"Mehanna","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"El Achy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf Hamza","family":"Taha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.11.016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-13535-4_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000546480.64441.af"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03546434"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90413-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0473"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(04)90008-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894081170S901"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.175"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.04.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00452-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000228006.21941.12"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700202"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185283"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1165-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v019a27"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03054-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0637"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282f0e116"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-020-00294-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/846062"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328220963920"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06276-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.734930"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2473"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20753"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24816"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102233"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489417739920"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.516"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000049"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24867"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.961920"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3242"}],"container-title":["The 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