{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:44:31Z","timestamp":1790891071346,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Management options for vestibular schwannoma include microsurgery (MS), stereotactic radiosurgery (SRS), and watch, wait, and rescan (WWR). This study aimed to evaluate changes in patient and disease\u2010specific quality of life (QoL) outcomes over time, comparing each treatment modality in a matched cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study recruited adult patients with sporadic vestibular schwannomas\u2009\u2264\u20093\u2009cm in size undergoing treatment between January 2012 and April 2022 in a single tertiary referral center. Questionnaires were completed at diagnosis and\u2009\u2265\u200912\u2009months posttreatment to assess patient\u2010reported changes in QoL (Hearing, Dizziness, Tinnitus Handicap Inventories; Penn Acoustic Neuroma QoL questionnaire (PANQOL) and the Short Form\u201036 QoL questionnaire (SF\u201036)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 124 patients returned completed questionnaires (MS: 42, SRS: 42, WWR 40). The SRS group had a clinically significant deterioration in their hearing scores posttreatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Dizziness scores worsened in the MS and WWR groups posttreatment; this did not reach clinical significance. Hearing deterioration was identified in the WWR group over time using the PANQOL domain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). The SF\u201036 questionnaire showed a significant deterioration in physical functioning, role limitations, and component summary for SRS patients posttreatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0018,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0032,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0308). No other significant differences were seen in disease\u2010specific or general QoL domains when comparing treatment strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Outcomes in similar disease\u2010specific domains were not consistent across questionnaires. All three treatment modalities appear to result in comparable long\u2010term disease\u2010specific QoL outcomes. These findings will enable evidence\u2010based patient counseling to inform decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32080","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:52:09Z","timestamp":1741719129000},"page":"2529-2537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quality of Life Outcomes in Vestibular Schwannoma: A Prospective Analysis of Treatment Modalities"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-8141","authenticated-orcid":false,"given":"A.","family":"Hotchkies","sequence":"first","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Heward","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wadeson","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Heal","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"King","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Pathmanaban","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Halliday","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Whitfield","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"McBain","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Colaco","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Goh","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K. W.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Manchester Skull Base Unit, Salford Royal Hospital  Manchester UK"},{"name":"Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211042006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200501000-00016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182595454"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"1","article-title":"Defining Clinically Significant Tumor Size in Vestibular Schwannoma to Inform Timing of Microsurgery During Wait\u2010And\u2010Scan Management: Moving Beyond Minimum Detectable Growth","volume":"136","author":"Macielak R. 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