{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:52:32Z","timestamp":1791687152047,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy"],"award-info":[{"award-number":["EXC 2145 SyNergy"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01 EO 0901"],"award-info":[{"award-number":["01 EO 0901"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012686","name":"Deutsche Stiftung Neurologie","doi-asserted-by":"publisher","award":["80766113"],"award-info":[{"award-number":["80766113"]}],"id":[{"id":"10.13039\/501100012686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>M\u00e9ni\u00e8re's disease (MD) and vestibular migraine (VM) can be associated with endolymphatic hydrops (ELH). The differential role of the endolymphatic sac and duct (ES\/ED) system for the development of ELH is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On 251 delayed, contrast\u2010enhanced inner ear MRI (iMRI) datasets from neurotological patients and healthy control participants, we evaluated (1) the visibility of the ES\/ED system using a novel semi\u2010quantitative scale, and (2) the dimensions of ELH, calculated using volumetric local thresholding (VOLT). Afterwards, statistical analysis of ES\/ED radiologic visibility in relation to the grade of ELH, the degree of clinical symptoms, and audiometric findings was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were divided into an MD cohort (<jats:italic>n<\/jats:italic>\u2009=\u200968, 34 females, mean age 54.5\u2009\u00b1\u200914.8\u2009years) and a VM cohort (<jats:italic>n<\/jats:italic>\u2009=\u200967, 42 females, 45.9\u2009\u00b1\u200915.5\u2009years). The remaining datasets did not fulfill diagnostic criteria for definite diagnoses (<jats:italic>n<\/jats:italic>\u2009=\u200964, 27 females, mean age 51.3\u2009\u00b1\u200916.6) or were from healthy controls (HC; <jats:italic>n<\/jats:italic>\u2009=\u200952, 27 females, 49.0\u2009\u00b1\u200918.1\u2009years). MD patients showed the lowest ES\/ED\u2010visibility scores on the affected side (ANOVA F(172,2): 20.60, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while the ES\/ED\u2010visibility on the non\u2010affected side in MD patients was still significantly lower than in VM and HC (ANOVA F(172,2): 6.80, p 1.44\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>). The ES\/ED\u2010visibility score and ELH volume (determined by VOLT, in mm<jats:sup>3<\/jats:sup>) correlated inversely (Spearman's rho: \u22120.32, Fisher's <jats:italic>z<\/jats:italic> \u22120.34, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ES\/ED radiologic visibility in iMRI is inversely associated with ELH volumes. Patients with MD show substantially decreased ES\/ED visibility on the affected ear and (less pronounced) on the unaffected ear, while VM and HC exhibit normal ES\/ED visibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence: 3.<\/jats:title><\/jats:sec>","DOI":"10.1002\/lary.32127","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:14:27Z","timestamp":1742372067000},"page":"2914-2922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contrast Agent Uptake in Endolymphatic Sac and Duct: Inverse Relation to Endolymphatic Hydrops"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-1462","authenticated-orcid":false,"given":"Johannes","family":"Gerb","sequence":"first","affiliation":[{"name":"German Center for Vertigo and Balance Disorders LMU University Hospital, LMU Munich  Munich Germany"},{"name":"Department of Neurology LMU 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Boegle","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders LMU University Hospital, LMU Munich  Munich Germany"},{"name":"Department of Neurology LMU University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brandt","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders LMU University Hospital, LMU Munich  Munich Germany"},{"name":"Department of Neurology LMU University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dieterich","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders LMU University Hospital, LMU Munich  Munich Germany"},{"name":"Department of Neurology LMU University Hospital, LMU Munich  Munich 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