{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:01:12Z","timestamp":1783382472222,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of spreader grafts in reduction septorhinoplasty on quality of life (QOL) outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Design<\/jats:title><jats:p>Randomized clinical trial (RCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals over 15\u2009years old with nasal obstruction were evaluated for functional and aesthetic septorhinoplasty from October 2018 to October 2022 at a facial plastic surgery clinic of a tertiary university hospital in Brazil. Participants were randomly allocated to subjects with or without spreader grafts. Primary outcome: Relative changes in specific Nasal Obstruction Symptom Evaluation in the Portuguese language (NOSE\u2010p). Outcomes were assessed at least 6 and 12\u2009months postoperatively (PO \u2265\u20096 and PO\u2009\u2265\u200912\u2009m). The participants and those assessing the outcomes were blinded to group assignment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 50 patients were included, 25 randomized to each group, mainly Caucasians with moderate\/severe allergic rhinitis symptoms. Mean age was 32.89\u2009\u00b1\u200913.36\u2009years and 68% were female. Septorhinoplasty improved specific quality\u2010of\u2010life scores irrespective of using spreader grafts (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no difference between subjects submitted or not to placement of spreader grafts in NOSE\u2010p score in PO \u2265\u20096\u2009m (\u221260.0 vs. \u221266.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.37); ROE in PO \u2265\u20096\u2009m (71.83 vs. 79.56; <jats:italic>p<\/jats:italic>\u2009=\u20090.35), NO\u2010VAS in PO \u2265\u20096\u2009m (13.00 vs. 8.00; <jats:italic>p<\/jats:italic>\u2009=\u20090,35), NOSE <jats:italic>p<\/jats:italic> in PO \u2265\u200912\u2009m (\u221253.14% vs. \u221268.33%; <jats:italic>p<\/jats:italic>\u2009=\u20090.28), ROE in PO \u2265\u200912\u2009m (76.33 vs. 79.53; <jats:italic>p<\/jats:italic>\u2009=\u20090.645), NO\u2010VAS in PO \u2265\u200912\u2009m (13.00 vs. 11.50; <jats:italic>p<\/jats:italic>\u2009=\u20090.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduction septorhinoplasty was associated with improvement in quality of life regarding nasal obstruction irrespective of using spreader grafts in a 7.88\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov identifier: (NCT0449946).<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32131","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:03:47Z","timestamp":1743887027000},"page":"3168-3177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Spreader Grafts in Reduction Septorhinoplasty: A Randomized Clinical Trial With Quality of Life Assessment"],"prefix":"10.1002","volume":"135","author":[{"given":"Raphaella","family":"Migliavacca","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Otorhinolaryngology and Head and Neck Surgery Department Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lavinsky","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Otorhinolaryngology and Head and Neck Surgery Department Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5804-4409","authenticated-orcid":false,"given":"Eduardo Priesnitz","family":"Friedrich","sequence":"additional","affiliation":[{"name":"School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Afonso","family":"de Freitas Toledo","sequence":"additional","affiliation":[{"name":"School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreza Mariane","family":"de Azeredo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Rossato","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-019-01343-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X11417427"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab409"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198402000-00013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2020.08.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.3991"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26831"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23628"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942012000400015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2015.1854"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02735-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489416685320"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2292550319880919"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005078"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003613"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2011.7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2940"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606097"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2018.2118"},{"key":"e_1_2_7_24_1","volume-title":"Tratado 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