{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:05:55Z","timestamp":1757617555818,"version":"3.44.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize patient demographics, tumor features, treatment patterns, and survival outcomes of adenoid cystic carcinoma of the middle ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of the Surveillance, Epidemiology, and End Results Database of the National Cancer Institute for all cases of histopathologically confirmed adenoid cystic carcinoma of the middle ear as the primary location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one patients with adenoid cystic carcinoma of the middle ear were identified. Patients had a median age of 61\u2009years (range 16\u201386) and were more commonly female (57.1%) and Caucasian (85.7%). Tumors had a median size of 11\u2009mm (range 5\u201322) with disease involvement most frequently locally (70%), followed by distant (20%), then regional disease (10%). Most underwent upfront surgery (85.7%) compared to radiation therapy (14.3%). Surgery was often followed by radiation. Five\u2010 and ten\u2010year disease\u2010specific survival remained stable at 67.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Demographics of middle ear adenoid cystic carcinoma reflect that of other primary locations, with a predilection for middle\u2010aged and female patients. Tumors more often present with local involvement, though distant metastasis is not uncommon. Surgery, followed by radiation, appears to be the favored treatment modality and generally portends a good prognosis, despite involvement of a complicated anatomic location. Further research is necessary to better characterize the disease and define its optimal management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32134","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T21:06:37Z","timestamp":1742591197000},"page":"2923-2928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing Adenoid Cystic Carcinoma of the Middle Ear\u2014A Rare Entity"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-8521","authenticated-orcid":false,"given":"Masanari G.","family":"Kato","sequence":"first","affiliation":[{"name":"Michigan Ear Institute  Farmington Hills Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8792","authenticated-orcid":false,"given":"Seilesh C.","family":"Babu","sequence":"additional","affiliation":[{"name":"Michigan Ear Institute  Farmington Hills Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2001.3636"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26740"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20202"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.102297"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2023.22850"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"39","article-title":"Primary Adenoid Cystic Carcinoma of the Middle Ear and Mastoid","volume":"47","author":"Magliulo G.","year":"1993","journal-title":"Acta Oto\u2010Rhino\u2010Laryngologica Belgica"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988309100120"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"31","article-title":"Adenoid Cystic Carcinoma of the Middle Ear and Mastoid Cavity With a Case Report","volume":"20","author":"Weaver R. J.","year":"1967","journal-title":"South Dakota Journal of Medicine"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2019.07.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2017.3929"},{"key":"e_1_2_8_12_1","unstructured":"National Cancer Institute \u201cSurveillance Epidemiology and End Results (SEER) Program \u201d2023. SEER*Stat Database: Incidence\u2014SEER Research Data www.seer.cancer.gov."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002391"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27408"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815607449"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:42:39Z","timestamp":1757144559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/lary.32134"],"URL":"https:\/\/doi.org\/10.1002\/lary.32134","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"2024-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}