{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:07:27Z","timestamp":1757617647204,"version":"3.44.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pulmonary embolism (PE) after surgery is a severe thrombotic event for patients suffering from head and neck malignancies. Our study analyzed the factors related to PE in such patients following radical resection. A case\u2010control study was designed to retrospectively investigate the factors associated with the increased risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2013 to 2022, 5042 radical resections were performed for head and neck malignancies. A control group, matched by age, gender, pathological diagnosis, and cancer stage, but without postoperative PE, was selected in a one\u2010to\u2010three ratio. The perioperative clinical data, encompassing hemodynamic management metrics, were subjected to univariate analyses. Conditional logistic regression modeling was implemented to quantify covariate effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of PE after surgery was 0.75% (95% CI\u2009=\u20090.55\u20131.03). Multivariable conditional logistic regression revealed PE after surgery was associated with cumulative time of the mean blood pressure (MBP) reductions &gt;\u200920% (OR\u2009=\u20093.167, 95% CI\u2009=\u20091.651\u20136.075, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), oliguria (OR\u2009=\u200944.055, 95% CI\u2009=\u20092.356\u2013823.886, <jats:italic>p<\/jats:italic>\u2009=\u20090.011), and bilateral neck dissection (OR\u2009=\u20093.291, 95% CI\u2009=\u20091.112\u20139.740, <jats:italic>p<\/jats:italic>\u2009=\u20090.031). The maximum area under the curve (AUC) for predicting PE was 0.809 (95% CI 0.716\u20130.902), achieved using cumulative hypotensive burden (MBP reductions &gt;\u200920%), with a classification threshold of 1.17\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative hypotension, oliguria, and bilateral neck dissection are significant predictors of postoperative PE following head and neck cancer surgeries. These findings underscore the importance of predictive clinical measures for effective risk control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32146","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:41:51Z","timestamp":1744872111000},"page":"3193-3201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Pulmonary Embolism After Head and Neck Cancers Resection: A Retrospective Case Control Study"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-8807","authenticated-orcid":false,"given":"Xuan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000384"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2020.11.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24758"},{"issue":"10","key":"e_1_2_8_7_1","first-page":"504","article-title":"Diagnosis and Treatment of Pulmonary Embolism in Patients After Operation of Head and Neck Malignant Tumor","volume":"22","author":"Zhou J.","year":"2015","journal-title":"Chinese Archives of Otolaryngology\u2013Head and Neck Surgery"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1549153"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70268-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31816fd7e7"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"547","article-title":"The Sunnybrook Experience: Review of Deep Vein Thrombosis and Pulmonary Embolism in Otolaryngology","volume":"37","author":"Lee J.","year":"2008","journal-title":"Journal of Otolaryngology \u2010 Head & Neck Surgery"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818756851"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818755340"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22920"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-021-01521-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.04.030"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.02.072"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-018-01801-w"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz726"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11688"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11\u20102297"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11\u20102404"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-072715","article-title":"Prevention of Venous Thromboembolism in Patients With Cancer","volume":"381","author":"Guntupalli S. R.","year":"2023","journal-title":"BMJ"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.06.009"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.09.004"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(03)00053-1"},{"issue":"113","key":"e_1_2_8_28_1","first-page":"343","article-title":"Internal Jugular Vein Thrombosis Following Different Types of Neck Dissection","volume":"32","author":"Motiee\u2010Langroudi M.","year":"2020","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1687144"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799504731"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-022-00442-7"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25970"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21331"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:50:22Z","timestamp":1757145022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/lary.32146"],"URL":"https:\/\/doi.org\/10.1002\/lary.32146","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2025-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}