{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:17:12Z","timestamp":1792034232107,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BESWIC20A0"],"award-info":[{"award-number":["BESWIC20A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BESWICK22Y5"],"award-info":[{"award-number":["BESWICK22Y5"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R25DC020151"],"award-info":[{"award-number":["R25DC020151"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF) and chronic rhinosinusitis (CRS). OD is associated with impaired quality of life (QOL) and dietary alterations in certain non\u2010CF populations. This study explored relationships between OD, QOL, and modulator use in PwCF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional analysis of an ongoing multicenter, prospective study (2019\u20132023) investigating PwCF with comorbid CRS. Participants completed the 40\u2010Question Smell Identification Test (SIT\u201040), 22\u2010question SinoNasal Outcome Test\u2010(SNOT\u201022), Questionnaire of Olfactory Disorders (QOD\u2010NS), and Cystic Fibrosis Questionnaire\u2010Revised (CFQ\u2010R). Clinical and sinus CT data were collected. After stratification by SIT\u201040 score, data was analyzed by chi\u2010square, Kruskal\u2013Wallis, Spearman correlation, and logistic regression to identify factors associated with OD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 59 participants, those with anosmia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) had worse eating\u2010related QOL (CFQ\u2010R eating) compared to individuals with normosmia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) and hyposmia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931). Participants with anosmia had worse sinus CT scores than those with hyposmia. Although PwCF treated with highly effective modulator therapy (HEMT;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) had better CT scores vs. non\u2010HEMT individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923), rates of OD in both groups were comparable. Higher SNOT\u201022 total scores were associated with increased odds of hyposmia or anosmia. In an eating\u2010related QOD\u2010NS subscore, those with worse CFQ\u2010R eating had 2.38 times higher odds of having OD. Each point decrease in CFQ\u2010R eating domain score was associated with 10% increased odds of OD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In PwCF, OD was associated with increased CRS severity, impaired olfactory QOL, and decreased CFQ\u2010R eating. There were no differences in SIT\u201040 or QOD\u2010NS scores based on HEMT status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT04469439\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32155","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:55:19Z","timestamp":1744692919000},"page":"2476-2488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-4775","authenticated-orcid":false,"given":"Christine 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