{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:39:22Z","timestamp":1789004362571,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate if dupilumab interval dose de\u2010escalation to every 4\u2009weeks negatively impacts treatment outcomes in real\u2010life practice for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) during the first 2\u2009years of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 148 patients who completed 2\u2009years of follow\u2010up. We compared two homogenous groups in terms of severity: group A included 77 patients who never modified the interval of administration during follow\u2010up; group B included 71 patients who extended the dosing interval to monthly administration. We compared the treatment outcomes and differences in safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The monthly interval dose prolongation was started in 22\/71 patients (30.99%) at 6\u2009months, in 11\/71 (15.48%) at 9\u2009months, in 22\/71 (30.99%) at 12\u2009months, and in 16\/71 (22.54%) at 18\u2009months. The dose prolongation was to manage minor adverse events in 9 of 71 patients; persistent eosinophilia in 26\/71 patients; specific request of patients who had confirmed sustained control as determined by the physician's assessment in 36\/71 cases. Mean values of all outcomes of response to treatment (i.e., volume of polyps, nasal obstruction, quality of life, olfaction) significantly improved at 6, 12, and 24\u2009months compared to baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) in both groups A and B. No significant differences were found comparing groups A and B for any of the outcomes examined over the 2\u2009years of follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that extending to monthly dosing of dupilumab in real life does not negatively impact outcomes in patients with severe uncontrolled CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32162","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T17:14:26Z","timestamp":1743354866000},"page":"2267-2274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dupilumab Monthly Dose De\u2010Escalation Maintains Efficacy in\n                    <scp>CRSwNP<\/scp>\n                    : A Two\u2010Year Real\u2010World Study"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De Corso","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-0314","authenticated-orcid":false,"given":"Claudio","family":"Montuori","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"De Maio","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Maria","family":"D'Auria","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Rizzuti","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"Pacilli","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mastrapasqua","sequence":"additional","affiliation":[{"name":"ENT Department Rivoli Hospital, ASL TO3  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario Antonio","family":"Mele","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Galli","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"},{"name":"Department of Head\u2010Neck and Sensory Organs Catholic University of Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.03.044"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-N1614"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"194","article-title":"EPOS\/EUFOREA Update on Indication and Evaluation of Biologics in Chronic Rhinosinusitis With Nasal Polyps 2023","volume":"61","author":"Fokkens W. J.","year":"2023","journal-title":"Rhinology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1783"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15796"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15772"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924231204128"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16263"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08790-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102684"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2043546"},{"issue":"5","key":"e_1_2_8_20_1","first-page":"1217","article-title":"An International, Retrospective Study of off\u2010Label Biologic Use in the Treatment of Hypereosinophilic Syndromes","volume":"10","author":"Chen M. M.","year":"2022","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2019.1585940"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14524"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000783"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15439"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08417-8"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T05:32:16Z","timestamp":1763098336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/lary.32162"],"URL":"https:\/\/doi.org\/10.1002\/lary.32162","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"2024-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}