{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:03:08Z","timestamp":1791946988513,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Add\u2010on dupilumab provides significant symptomatic improvement for individuals with chronic rhinosinusitis with nasal polyps (CRSwNP); however, little is known about the impact of dupilumab in reducing rates of rescue treatment for CRSwNP in Japanese real\u2010world practice settings. This observational study examined the impact of add\u2010on dupilumab treatment on disease burden, including the use of rescue therapy, in Japanese individuals with CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study analyzed individual participant data from a Japanese hospital\u2010based administrative claims database between January 1, 2019, and March 31, 2023. Data were collected for each individual from 12\u2009months prior to the index date (the start date of dupilumab administration) to 12\u2009months after the index date (follow\u2010up period). The primary outcome was the change in overall rate of rescue treatment (systemic corticosteroid [SCS] use or endoscopic sinus surgery [ESS]) before and after the initiation of dupilumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 438 individuals with CRSwNP (mean\u2009\u00b1\u2009SD age of 53.9\u2009\u00b1\u200913.4\u2009years; 56.6% male). The overall rate of rescue treatment before and after initiation of dupilumab treatment was 7.89 events per patient\u2010year (PY) and 2.14 events per PY, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and there was a 73% reduction in the rate of rescue treatment. Compared with the pre\u2010index period, a lower rate of SCS prescriptions (7.54 vs. 2.05) and ESS procedures (0.35 vs. 0.05) during the follow\u2010up was observed, respectively, and there was a 72% reduction in the rate of SCS prescriptions. The mean\u2009\u00b1\u2009SD daily SCS dose decreased from 7.1\u2009\u00b1\u20099.7\u2009mg in the pre\u2010index period to 6.1\u2009\u00b1\u20097.3\u2009mg during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this real\u2010world study, add\u2010on dupilumab treatment significantly reduced the requirement for rescue treatment in Japanese individuals with CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32171","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:09:17Z","timestamp":1748311757000},"page":"3093-3103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduction of Rescue Treatment With Dupilumab for Chronic Rhinosinusitis With Nasal Polyps in Japan"],"prefix":"10.1002","volume":"135","author":[{"given":"Mamoru","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology International University of Health and Welfare School of Medicine  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-8586","authenticated-orcid":false,"given":"Makiko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Sanofi K.K.  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