{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:32:55Z","timestamp":1791646375539,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Dupilumab is a fully humanized monoclonal antibody that interferes with the inflammatory cascade in type\u20102 Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Studies evaluating its safety and efficacy in the long term are still few. Our study analyzed outcomes and adverse events after 1, 3, 6, 12, 24, 36, and 48\u2009months of dupilumab administration in patients affected by CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A monocentric, retrospective study assessing blood eosinophil (BEC) and total IgE count, Sinonasal Outcome Test\u201022 (SNOT\u201022), Nasal Polyps Score (NPS), sniffin\u2019 sticks identification test (SSIT\u201016), and Lund\u2010Mackay score (LMS) in patients receiving subcutaneous Dupilumab 300\u2009mg\/2\u2009weeks for at least 1\u2009year and up to 4\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients were enrolled, of whom 70, 38, 25, and 12 completed a 12, 24\u2010, 36\u2010, and 48\u2010month follow\u2010up period, respectively. Patients showed a very rapid and long\u2010lasting statistically significant improvement in their SNOT\u201022, NPS, and SSIT after 1\u2009month, and this trend was kept in the following 48\u2009months. The total IgE count has been constantly reducing over the study period. BEC increased in the first 6\u2009months and then gradually decreased over time, reaching an even smaller value than baseline at 36 and 48\u2009months. Four patients (5.9%) complained of severe adverse events within 6\u2009months, with two interrupting treatment due to hypereosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dupilumab was safe and effective in extinguishing the symptomatologic burden of CRSwNP as early as 1\u2009month and up to 48\u2009months, with side events limited to the first 6\u2009months of administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32205","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:29:58Z","timestamp":1745396998000},"page":"3104-3111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sustained Efficacy and Low Rate of Adverse Events of Dupilumab in Type\u20102 <scp>CRSwNP<\/scp> Over 48\u2009Months"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-2407","authenticated-orcid":false,"given":"Pietro","family":"Orlando","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-3607","authenticated-orcid":false,"given":"Giuseppe","family":"Licci","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Illiano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2398-7712","authenticated-orcid":false,"given":"Alberto","family":"Minzoni","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Vivarelli","sequence":"additional","affiliation":[{"name":"Immunoallergology Unit Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Accinno","sequence":"additional","affiliation":[{"name":"Immunoallergology Unit Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Vultaggio","sequence":"additional","affiliation":[{"name":"Immunoallergology Unit Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Matucci","sequence":"additional","affiliation":[{"name":"Immunoallergology Unit Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2741-4460","authenticated-orcid":false,"given":"Giandomenico","family":"Maggiore","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Careggi University Hospital  Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.08.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13373"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4076"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27815"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1305426"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804092"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31881\u20101"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201008725\u20107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23212"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2022.2090342"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010016\u20104313\u2010x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010018\u20105248\u20101"},{"key":"e_1_2_7_17_1","first-page":"183","article-title":"Staging in Rhinosinusitis","volume":"4","author":"Lund V. 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