{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:36:50Z","timestamp":1762504610660,"version":"3.44.0"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited research exists on the prevalence and comorbidity of dysphagia and dysphonia, though prior studies highlight their co\u2010existence in multiple disease cohorts. This study investigates the prevalence of dysphonia in U.S. adults with dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted using the NIH's All of Us Research Program controlled tier dataset (version 7). Multivariate logistic regression and marginal effects (ME) examined the association of dysphonia in U.S. adults with dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 266,612 adults, 24,198 had dysphagia (median age, 67\u2009years; 63% female), and 242,414 did not (median age, 58\u2009years; 61% female). Dysphonia was significantly more prevalent in patients with dysphagia (14% vs. 1.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analysis showed a 6.78\u2010fold increase in odds of dysphonia with dysphagia (95% CI 6.47\u20137.11; ME 9.82%). Dysphagia was significantly associated with dysphonia in patients with head and neck cancer (aOR 2.93; ME 13.51%), stroke (aOR 3.71; ME 14.56%), neurodegenerative conditions (aOR 4.34; ME 13.16%), COPD (aOR 4.33; ME 13.35%), ACDF (aOR 5.24; ME 18.90%), and vocal fold abnormalities (aOR 1.40; ME 7.71%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with dysphagia had a 6.78\u2010fold increase in odds of having a diagnosis of dysphonia. Otolaryngologists and speech\u2010language pathologists should consider dysphonia assessment in their patients presenting with dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32239","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T07:08:15Z","timestamp":1746256095000},"page":"3248-3256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Dysphonia in Patients With Dysphagia in the United States: A National Database Study"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-1278","authenticated-orcid":false,"given":"Linh","family":"He","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery, Weill Cornell Medical College Sean Parker Institute for the Voice  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery, Weill Cornell Medical College Sean Parker Institute for the Voice  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-6364","authenticated-orcid":false,"given":"James","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery, Weill Cornell Medical College Sean Parker Institute for the Voice  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camonia","family":"Graham\u2010Tutt","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Natural and Health Sciences University of Hawai'i\u2010West O'ahu  Kapolei Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2634","authenticated-orcid":false,"given":"Ana\u00efs","family":"Rameau","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery, Weill Cornell Medical College Sean Parker Institute for the Voice  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817751031"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2019.07.022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175893"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s409828"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010022\u201010465\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2021.05.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.09.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13150"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15152"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.0698"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25481"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0013.4123"},{"key":"e_1_2_9_14_1","unstructured":"NIH \u201cAll of Us Research Program \u201daccessed January 9 2025 https:\/\/allofus.nih.gov\/."},{"key":"e_1_2_9_15_1","unstructured":"Join All of Us \u201cWho Can Join \u201daccessed January 9 2025 https:\/\/www.joinallofus.org\/who\u2010can\u2010join."},{"volume-title":"R Foundation for Statistical Computing","year":"2023","author":"R Core Team","key":"e_1_2_9_16_1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010023\u201010570\u20105"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711601112"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24917"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814549156"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1044\/2024_ajslp\u201023\u201000407"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010024\u201010693\u20103"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113225"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13089"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2018.05.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000536231"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270096"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148424"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000190056.76543.eb"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015947"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.12786\/bn.2022.15.e29"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010022\u201006469\u2010y"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17840"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00406.2002"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2016.40.4.600"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757\u20101626\u20101\u201067"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.5762\/kais.2012.13.4.1665"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010024\u201007782\u20104"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.03.043"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010023\u201010566\u20101"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010024\u201010720\u20103"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000540457"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/14015439.2020.1771766"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1044\/2022_jslhr\u201022\u201000363"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1044\/2024_ajslp\u201024\u201000194"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.11.015"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010955118"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s194723"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1044\/2014_jslhr\u2010s\u201013\u20100168"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0b013e32832af12f"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26059"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.09.007"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00401"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3171\/spi\u201007\/08\/124"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2021.02.011"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002704"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29326"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004550000026"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537\u2010200210000\u201000025"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30255"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2018.05.003"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.12.002"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807\u20101139oc"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s257622"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2022.05.017"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211031449"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0000000000000153"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.12.038"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:49:59Z","timestamp":1757144999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,3]]},"references-count":67,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/lary.32239"],"URL":"https:\/\/doi.org\/10.1002\/lary.32239","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2025,5,3]]},"assertion":[{"value":"2025-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}