{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:31:19Z","timestamp":1784536279179,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR303052"],"award-info":[{"award-number":["NIHR303052"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adult acquired laryngotracheal stenosis (LTS) is a chronic condition with heterogeneous treatment options and a significant symptom burden. Synthesis of data across research studies to guide clinical decision\u2010making is challenging due to inconsistent outcome selection and use of unvalidated measures. Our objective was to establish a core outcome set (COS) for studies of LTS interventions in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a two\u2010round modified e\u2010Delphi study. We reviewed published systematic reviews and qualitative studies to inform the inclusion of 42 outcomes in the first e\u2010Delphi round, with 10\u2009additional outcomes added by participants for the second voting round. The international expert panel included clinicians, researchers, and people living with LTS. We held two consensus meetings and a final voting round.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first e\u2010Delphi round involved 1067 participants from multiple stakeholder groups, with 575 participants voting in the second. Seventeen participants participated in the consensus meetings. The final COS included seven outcomes: (1) Level of breathlessness, (2) Ability to generate audible voice, (3) Ability to manage\/clear mucus, (4) Ability to eat and drink, (5) Health\u2010related quality of life, (6) Emotional and mental health symptoms, and (7) Frequency of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By using a rigorous Delphi process informed by multiple stakeholder groups, we gained consensus on seven core outcomes for inclusion in future research relating to LTS. Use of this COS will standardize outcomes measured in future research studies, ensuring they are comparable. Future work is required to identify the best way to measure these outcomes to fully operationalize this COS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level V.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32262","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T21:43:28Z","timestamp":1747086208000},"page":"3756-3765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of a Core Outcome Set for Intervention Studies in Adults With Laryngotracheal Stenosis"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-731X","authenticated-orcid":false,"given":"Gemma M.","family":"Clunie","sequence":"first","affiliation":[{"name":"Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-6421","authenticated-orcid":false,"given":"Amy","family":"Freeman\u2010Sanderson","sequence":"additional","affiliation":[{"name":"Graduate School of Health, University of Technology Sydney  Chippendale New South Wales Australia"},{"name":"Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Critical Care Division The George Institute for Global Health, Faculty of Medicine, UNSW Sydney  Sydney Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre (ANZIC\u2010RC), school of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-5096","authenticated-orcid":false,"given":"Chadwan","family":"Al\u2010Yaghchi","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-3124","authenticated-orcid":false,"given":"Justin W. G.","family":"Roe","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-8939","authenticated-orcid":false,"given":"Caroline","family":"Alexander","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guri","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-332X","authenticated-orcid":false,"given":"Alison","family":"McGregor","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-3972","authenticated-orcid":false,"given":"Louise","family":"Rose","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Midwifery and Palliative Care, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Laryngeal and Tracheobronchial Stenosis","author":"Sandhu G.","year":"2015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20104486.2007.01484.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24956"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26098"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.03.07"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818815068"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.4517"},{"issue":"6","key":"e_1_2_8_9_1","first-page":"1834","article-title":"Long\u2010Term Results and Functional Outcomes After Surgical Repair of Benign Laryngotracheal Stenosis","volume":"11","author":"Nauta A.","year":"2020","journal-title":"Annals of Thoracic Surgery"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28494"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26151"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1978-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002447"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v11.i4.116"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28494"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1460-6984.12794"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894211050627"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-021-10287-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.12.020"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39490.551019.BE"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-132"},{"key":"e_1_2_8_22_1","first-page":"655","article-title":"How to Use the Nominal Group and Delphi Techniques","volume":"38","author":"McMillan S. 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