{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:10:45Z","timestamp":1777097445438,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cochlear implantation in otosclerosis patients presents unique surgical and programming challenges. The success and satisfaction of these patients heavily depend on precise speech processor fitting. Increased bone growth and tissue mass associated with otosclerosis can hinder electrical current flow, adding resistance to stimuli transmission to ganglion cells. This study aimed to evaluate mid\u2010 and long\u2010term cochlear implant fitting in otosclerosis patients compared to a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a monocentric retrospective case\u2013control study conducted at a tertiary referral center comparing patients with far advanced otosclerosis and a control group of post\u2010lingually deafened individuals from the same database. Data collected included: age, sex, etiology, hearing deprivation duration, implantation age and side, surgical details, postoperative complications (e.g., tinnitus, dizziness, or facial nerve stimulation), hearing tests, and cochlear implant fitting details.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study analyzed 80 patients: 29 with otosclerosis and 51 controls. Higher impedances were seen in the otosclerosis group at 2 and 5\u2009years, statistically significant for basal, middle, and overall electrodes at 2\u2009years. Higher C\u2010 and T\u2010levels for apical electrodes at 2\u2009years were identified, and neural response telemetry thresholds were significantly higher for medial and apical electrodes in otosclerosis patients at 2\u2009years. Despite these differences, auditory outcomes at 5\u2009years were comparable between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest significant tissue remodeling at the cochlear apex in otosclerosis patients, likely increasing resistance to electrical currents delivered by the implant. This highlights the importance of tailored programming and long\u2010term monitoring for otosclerosis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32271","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:49:16Z","timestamp":1747633756000},"page":"3885-3892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Cochlear Implant Sensitivity in Patients With Far Advanced Otosclerosis"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-121X","authenticated-orcid":false,"given":"Rapha\u00eble","family":"Quatre","sequence":"first","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery University Hospital, Grenoble Alpes  France"},{"name":"GeodAIsics  Grenoble France"},{"name":"BrainTech Lab INSERM UMR 2015  Grenoble France"},{"name":"Department of CLINTEC, Div of Otorhinolaryngology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Bonnard","sequence":"additional","affiliation":[{"name":"Department of CLINTEC, Div of Otorhinolaryngology Karolinska Institutet  Stockholm Sweden"},{"name":"Medical Unit of ENT, Hearing and Balance Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Wales","sequence":"additional","affiliation":[{"name":"Department of CLINTEC, Div of Otorhinolaryngology Karolinska Institutet  Stockholm Sweden"},{"name":"Medical Unit of ENT, Hearing and Balance Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ekl\u00f6f","sequence":"additional","affiliation":[{"name":"Department of CLINTEC, Div of Otorhinolaryngology Karolinska Institutet  Stockholm Sweden"},{"name":"Medical Unit of ENT, Hearing and Balance Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-07036-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200103000-00023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001552"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182565a0e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21904"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000692"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1224"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946107000411"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28632"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.984"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106773"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1808\u20108694(15)31271\u20104"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"10","article-title":"Intraoperative Neural Response Telemetry and Neural Recovery Function: A Comparative Study Between Adults and Children","volume":"19","author":"Carvalho B.","year":"2015","journal-title":"International Archives of Otorhinolaryngology"},{"issue":"2","key":"e_1_2_8_15_1","first-page":"111","article-title":"Longitudinal Variations in Fitting Parameters for Adult Cochlear Implant Recipients","volume":"34","author":"Mosca F.","year":"2014","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2024.112001"},{"issue":"6","key":"e_1_2_8_17_1","first-page":"487","article-title":"Synchrotron Phase\u2010Contrast Imaging and Cochlear Otosclerosis: A Case Report","volume":"29","author":"Giese D.","year":"2024","journal-title":"Audiology & Neurotology"},{"issue":"35","key":"e_1_2_8_18_1","first-page":"1303","article-title":"Speech Audiometry","volume":"46","author":"Liden G.","year":"1951","journal-title":"Nordisk Medicin"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2016.04.015"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:49:38Z","timestamp":1758952178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/lary.32271"],"URL":"https:\/\/doi.org\/10.1002\/lary.32271","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2025-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}