{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T16:01:40Z","timestamp":1771084900713,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009993","name":"Center for Clinical and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011248","name":"CoMotion, University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["1R21DE033120\u201001"],"award-info":[{"award-number":["1R21DE033120\u201001"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To develop and validate a novel diagnostic modality to quantify upper airway obstruction (UAO) in patients with Robin Sequence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical and imaging data were retrospectively collected for 10 patients with Robin Sequence (RS) who underwent dynamic upper airway computed tomography (4D\u2010CT). 4D\u2010CT data were analyzed using computational fluid dynamics (CFD) methodologies. For each subject, the following CFD variables were calculated: airway resistance, peak velocity, energy dissipation, and minimal cross\u2010sectional area. Clinical data, including method of respiratory support, level of respiratory support, blood CO\n                      <jats:sub>2<\/jats:sub>\n                      level, and polysomnogram results, were also examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The integration of 4D\u2010CT with CFD yielded an anatomically precise representation of airflow features at inspiration and expiration relative to the more conventional measures of cross\u2010sectional area. Comparing the most severe to the least severe patient, 32x, 24\u00d7, and 5\u00d7 greater values for resistance, viscous dissipation, and peak velocity at peak inspiration were observed. Clinical severity appeared related to the strength of jet formation and large velocity gradients downstream of the obstructions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>4D\u2010CT\/CFD acquisition and analyses in RS patients appear to have beneficial descriptive utility at identifying critical anatomical loci and flow restrictions on a patient\u2010by\u2010patient basis. With further studies, this diagnostic approach for neonates and young children with UAO has the potential to inform severity assessment and guide surgical decision\u2010making. Additional data and expanded metrics will be helpful to refine and extend these observations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32274","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:38:43Z","timestamp":1748853523000},"page":"4396-4403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Novel Diagnostic Modality for Upper Airway Obstruction in Neonates"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-3576","authenticated-orcid":false,"given":"J. P.","family":"Dahl","sequence":"first","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2014Head &amp; Neck Surgery Children's Mercy  Kansas City Missouri USA"},{"name":"Children's Mercy Research Institute  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Barbour","sequence":"additional","affiliation":[{"name":"Center for Respiratory Biology and Therapeutics, Seattle Children's  Seattle Washington USA"},{"name":"Department of Mechanical Engineering University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-4724","authenticated-orcid":false,"given":"S. N.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. E.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Bindschadler","sequence":"additional","affiliation":[{"name":"Center for Respiratory Biology and Therapeutics, Seattle Children's  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-527X","authenticated-orcid":false,"given":"R. A.","family":"Bly","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery University of Washington  Seattle Washington USA"},{"name":"Division of Pediatric Otolaryngology\u2014Head &amp; Neck Surgery Seattle Children's  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Center for Respiratory Biology and Therapeutics, Seattle Children's  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-3997","authenticated-orcid":false,"given":"J. A.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery University of Washington  Seattle Washington USA"},{"name":"Division of Pediatric Otolaryngology\u2014Head &amp; Neck Surgery Seattle Children's  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Aliseda","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2014Head and Neck Surgery Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0796"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2615"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000510"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618756706"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2024.02.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2024.04.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27140"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.109855"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2020.105627"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010019\u201002410\u20101"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211002156"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-022-03036-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211027353"},{"key":"e_1_2_8_16_1","first-page":"6714","article-title":"Adaptive Accelerometry Derived Respiration: Comparison With Respiratory Inductance Plethysmography During Sleep","volume":"2019","author":"Bricout A.","year":"2019","journal-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.144"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2020.03.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.5.1385"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105959"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03181864"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10367-w"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219642"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00746.2013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26954"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29169"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25482"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.11.033"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27006"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.32274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:01:53Z","timestamp":1771081313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/lary.32274"],"URL":"https:\/\/doi.org\/10.1002\/lary.32274","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}