{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:06:38Z","timestamp":1757617598232,"version":"3.44.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Frail individuals have diminished muscle strength and may experience swallowing dysfunction. While studies have demonstrated associations between frailty and oropharyngeal dysphagia, few have examined the impact of frailty on instrumental measures of oropharyngeal swallowing. Our objective was to compare quantitative measures of oropharyngeal swallowing during videofluoroscopic swallow study (VFSS) in patients with mild frailty compared to no frailty, based on the Modified Frailty Index\u201011 (mFI\u201011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted among adults undergoing VFSS. Hyoid displacement (HD), posterior pharyngeal wall thickness (PPW), and pharyngoesophageal segment (PES) opening were quantified and compared between those with \u201cno frailty\u201d and \u201cmild frailty,\u201d defined as an mFI\u201011 score of 0 and 1, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four patients were included in this study (no frailty, <jats:italic>n<\/jats:italic>\u2009=\u200924 and mild frailty, <jats:italic>n<\/jats:italic>\u2009=\u200920), including 28 females, with an overall median age of 47.5 (range 18\u201385). There was no significant difference in HD on 1\u2010mL bolus (95% CI: \u22120.53 to 0.66, <jats:italic>p<\/jats:italic>\u2009=\u20090.82), 20\u2010mL bolus (95% CI: \u22120.89 to 0.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.33), PPW at rest (95% CI: \u22120.22 to 0.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.22), PPW at maximal constriction (95% CI: \u22120.12 to 1.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.11), and PES (95% CI: \u22120.95 to 0.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HD, PPW, and PES opening appear to be preserved among individuals with mild frailty. Deficits in oropharyngeal swallow, however, may be more apparent in moderate and severe frailty as well as those with comorbid sarcopenia. Future studies may consider including patients with advanced frailty as well as using direct measures of muscle mass\/strength such as imaging findings and grip strength to capture the association between frailty and oropharyngeal dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.32277","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T07:59:05Z","timestamp":1747814345000},"page":"3112-3119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Mild Frailty on Quantitative Measures of Oropharyngeal Swallow"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-3417","authenticated-orcid":false,"given":"Alice","family":"Cheng","sequence":"first","affiliation":[{"name":"Albany Medical College  Albany New York 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C.","family":"Pryor","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology \u2013 Head and Neck Surgery University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Z.","family":"Gao","sequence":"additional","affiliation":[{"name":"UChicago Voice Center, Department of Surgery, Section of Otolaryngology \u2013 Head and Neck Surgery University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neel K.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology \u2013 Head and Neck Surgery University of Washington School of Medicine  Seattle Washington 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