{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:33:50Z","timestamp":1773189230653,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>RADA\u201016 is a self\u2010assembling peptide matrix with the ability to form a hydrogel structure, showing promise for improved wound healing and hemostasis. Our objective was to understand the utility of RADA\u201016 on postoperative bleeding rates following inferior turbinate submucosal resection (ITR) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic health records of patients who underwent ITR surgery with a single surgeon from January 2020 to March 2024 were reviewed. Univariate and multivariate analyses were performed to determine differences in postoperative epistaxis rates between RADA\u201016 and non\u2010RADA\u201016 cohorts. Further analysis was performed to compare healthcare\u2010associated costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis included 985 patients who underwent ITR, of whom 571 received RADA\u201016 and 414 did not. Overall, 1.11% of patients experienced postoperative bleeding, 0.35% in the RADA\u201016 cohort and 2.17% in the non\u2010RADA\u201016 cohort. Patients receiving RADA\u201016 had a significantly lower risk of postoperative hemorrhage (OR 0.17, 95% CI 0.036\u20130.808,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). Comparison of the two cohorts showed no significant difference in the prevalence of additional nasal surgery or bleeding disorders. The non\u2010RADA\u201016 group was more likely to be on anticoagulation treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); however, no relationship between anticoagulant usage and bleeding episodes was observed. After cost\u2010effectiveness analysis, we found the bleeding cost per patient was $379.74 for the RADA\u201016 group and $436.21 for the non\u2010RADA\u201016 group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.36).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RADA\u201016 is believed to improve wound healing and hemostasis. In our study, we found that patients receiving RADA\u201016 are less likely to experience epistaxis following ITR surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32278","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:40:59Z","timestamp":1747644059000},"page":"4081-4085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>RADA<\/scp>\n                    \u201016 Reduces Postoperative Epistaxis After Inferior Turbinate Submucosal Resection"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5276-860X","authenticated-orcid":false,"given":"Annie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9731-9429","authenticated-orcid":false,"given":"Emily","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-0692","authenticated-orcid":false,"given":"Alexandra","family":"Filipkowski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Y.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Filimonov","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-7818","authenticated-orcid":false,"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Otolaryngology and Facial Plastic Surgery Saint Barnabas Medical Center\u2014RWJBarnabas Health  Livingston New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne Daniel","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392\u2010100X\u2010964"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110128"},{"key":"e_1_2_7_4_1","unstructured":"National Institute of Health Efficacy of PuraSinus Versus Bioresorbable Nasal Dressings 2024."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.239"},{"key":"e_1_2_7_6_1","unstructured":"\u201cPuraSinus \u201d 2019 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