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After that, two reviewers independently screened the retrieved articles, extracted the pertinent data, and assessed the risk of bias in the included studies. Then we used Stata 14.2 to perform a network meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninteen randomized controlled trials (RCTs) and 2354 participants were included. Compared with placebo, biologics demonstrated the most significant improvement in subjective olfactory dysfunction (OD) [standardized mean difference (SMD)\u2009=\u2009\u22120.75, 95% confidence intervals (CI) (\u22121.08, \u22120.41)]. In terms of objective olfactory function improvement, biologics also exhibited the greatest effect (SMD\u2009=\u20090.93, 95% CI [0.56, 1.31]). Among various biologics, dupilumab was the most effective in alleviating both subjective OD (SMD\u2009=\u2009\u22121.30, 95% CI [\u22121.51, \u22121.09]) and objective OD (mean difference [MD]\u2009=\u200911.13, 95% CI [9.91, 12.35]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our research results indicated that biologics might show better performance in terms of improving the olfactory sensation of patients with CRSwNP, particularly dupilumab. However, given the limitations of this study, future research should employ more standardized olfactory assessment methods and conduct more large\u2010scale RCTs, ultimately guiding clinicians and patients in making informed and optimal treatment choices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>NA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32289","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T07:35:22Z","timestamp":1748331322000},"page":"3976-3988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Different Types of Medications on Olfactory Dysfunction in\n                    <scp>CRSwNP<\/scp>\n                    : A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7154-9000","authenticated-orcid":false,"given":"Lei","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Health Preservation and Rehabilitation Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Preclinical Medicine Chengdu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Health Preservation and Rehabilitation Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Health Preservation and Rehabilitation Chengdu 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