{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:35:09Z","timestamp":1791473709911,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the temporal and bidirectional relationships between tinnitus subtypes\u2014pulsatile tinnitus (PT) and non\u2010pulsatile tinnitus (NPT)\u2014and psychiatric conditions, specifically generalized anxiety disorder (GAD) and major depression (MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilized data from the TriNetX Research Network, including over 140\u2009million patients. Patients were categorized based on ICD\u201010 codes for PT, NPT, GAD, and MD. Propensity score matching (PSM) was applied to control for demographic and clinical confounders. Statistical analyses included chi\u2010square tests, odds ratios (OR) with 95% confidence intervals (CIs) to ascertain the statistical significance of temporal associations between tinnitus subtypes and psychiatric conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NPT patients had significantly higher risks of developing GAD and MD than PT patients. PSM analyses confirmed that PT patients had consistently lower risks of developing these conditions, even across treated and untreated subgroups. Among patients with tinnitus, those with PT had significantly higher rates of pre\u2010existing GAD and MD compared to those with NPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NPT is associated with significantly higher risks of developing GAD and MD compared to PT, highlighting a greater psychiatric burden among this subgroup. Conversely, patients with tinnitus who had pre\u2010existing GAD or MD were more likely to have PT than NPT, suggesting a bidirectional relationship. These findings underscore the importance of integrating mental health assessment into tinnitus care and inform future research into subtype\u2010specific management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32290","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T05:00:15Z","timestamp":1748062815000},"page":"4328-4340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bidirectional Associations Between Tinnitus Subtypes and Psychiatric Conditions"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-5067","authenticated-orcid":false,"given":"Daniel","family":"Karasik","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University Hospitals Cleveland Medical Center  Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Katragadda","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4020-8502","authenticated-orcid":false,"given":"Alayna","family":"Kinkead","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-6535","authenticated-orcid":false,"given":"David J.","family":"Eisenman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107007\u20107\u201080"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010010\u20100163\u20101"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-72561-1_4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000306630"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2009.09.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1463\u20101741.53362"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.20.5.5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201008561\u20109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43042\u2010024\u201000520\u20107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992020802716786"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2016.1198966"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031169"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"37","article-title":"Health and Nutrition Examination Survey of 1971\u201075: Part II. 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