{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:45:10Z","timestamp":1772750710897,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071053"],"award-info":[{"award-number":["82071053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the molecular findings and long\u2010term outcomes of cochlear implantation (CI) in a relatively large cohort of patients with incomplete partition type\u2010III malformation (IP\u2010III), and to analyze the correlation between genotype and CI outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional (genomic) and retrospective cohort (auditory and speech outcomes with CI) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children diagnosed with IP\u2010III who underwent CI at a tertiary referral center were enrolled. Comprehensive genetic analyses were performed for each participant. Postoperative auditory and speech abilities with CI were retrospectively analyzed. Correlations between different mutation types and CI outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen children from 17 families were included. All participants had genetic variations, with seven novel variants on the\n                      <jats:italic>POU3F4<\/jats:italic>\n                      exon and four novel copy number variations (CNVs) on Xq21.1. Most children showed great auditory and speech improvement after long\u2010term rehabilitation with CI, but their speech recognition rates varied considerably. Children with variants affecting amino acid sequences of POU domains showed better preimplantation performance and older age of implantation, but their long\u2010term auditory and speech abilities were comparable to those with complete loss of POU domains. Children with CNVs upstream of\n                      <jats:italic>POU3F4<\/jats:italic>\n                      had greatly improved auditory and speech abilities, whereas those with large deletions showed only some improvement in sound detection ability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study expands the mutation spectrum of\n                      <jats:italic>POU3F4<\/jats:italic>\n                      and provides initial evidence for potential associations between genetic variations and CI outcomes in children with IP\u2010III malformation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32304","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:45:41Z","timestamp":1748940341000},"page":"4419-4427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genotype and Outcomes of Cochlear Implantation in Children With Incomplete Partition Type\n                    <scp>III<\/scp>"],"prefix":"10.1002","volume":"135","author":[{"given":"Xiuhua","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfen","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhua","family":"Ji","sequence":"additional","affiliation":[{"name":"Precision Medicine Engineering Research Center of Shandong Yinfeng Gene Technology Co. Ltd.  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangxia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaomin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-6042","authenticated-orcid":false,"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan People's Republic of China"},{"name":"Department of Auditory Implantation Shandong Second Provincial General Hospital  Jinan People's Republic of China"},{"name":"Shandong Provincial Key Laboratory of Deafness and Vertigo Diseases  Jinan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00913.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26245"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.2017.0367"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7839145"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.07.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000059101"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01181.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.850"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182839864"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820932138"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415604167"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25573"},{"key":"e_1_2_9_14_1","article-title":"Cochlear 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