{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:22:27Z","timestamp":1778592147397,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060186"],"award-info":[{"award-number":["82060186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of ropivacaine with dexamethasone spray for postoperative pain relief in adults undergoing tonsillectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 172 adult patients were randomly assigned to four groups: RD group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) received topical 1% ropivacaine with dexamethasone spray, RP group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) received topical 1% ropivacaine spray, Saline group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) received topical saline spray, and Control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943): not receive any interventions. The groups were compared on resting pain scores at 1, 2, 3, 5, 7, and 10\u2009days, changes in pain scores over 10\u2009days, adverse reactions (including dizziness, nausea, difficulty opening the mouth, and pharyngeal foreign body sensation), the time to first solid food intake, the time to first oral pain medication, and total pain medication dosage within 10\u2009days postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The RD group had significantly lower resting pain scores at 1, 2, 3, 5, 7, and 10\u2009days compared to the other groups, as well as a greater decrease in pain scores over 10\u2009days, correlated with Body Mass Index (BMI) and independent of age. They also had earlier postoperative oral intake of solid food, reduced need for remedial analgesics, and lower incidence of difficulty opening the mouth, halitosis, and pharyngeal foreign body sensation compared to the RP, Saline, and Control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Topical 1% ropivacaine with dexamethasone spray is easy to administer for postoperative tonsillar pain relief in adults. The dosage can be adjusted to meet patient needs, effectively addressing pain with fewer side effects, making it clinically useful and applicable.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of Evidence:<\/jats:bold>\n                      2.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32350","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T08:39:30Z","timestamp":1750322370000},"page":"4669-4679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical Ropivacaine Combined With Dexamethasone Spray Relieves Post\u2010Tonsillectomy Pain in Adults"],"prefix":"10.1002","volume":"135","author":[{"given":"Zhi\u2010qiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine The First Clinical Medical College, Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010wei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010qi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010xu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Medical Center of Anesthesiology and Pain The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010tong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Yanbian University Hospital  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8539-9849","authenticated-orcid":false,"given":"Xin\u2010hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319846065"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32833fad0a"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070\u2010011\u20100357\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022113"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.10.74"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121871"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S372071"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14040702"},{"issue":"4","key":"e_1_2_10_11_1","first-page":"E39","article-title":"Role of Intraoperative Ropivacaine in Adult Post\u2010Tonsillectomy Pain Control: A Randomized Controlled Trial","volume":"96","author":"Yao W. 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